On July 19, 2023, Singular Genomics Systems, Inc. (the ?Company?) entered into an agreement for termination of lease (as amended, the ?Lease Termination Agreement?) with an affiliate of Alexandria Real Estate Equities, Inc. (?ARE?). Pursuant to the Lease Termination Agreement, the Company and ARE agreed to terminate that certain lease agreement entered into by the parties in January 2022 (the ?OAS Lease?) for the lease of two buildings to be constructed in connection with One Alexandria Square in La Jolla, California (the ?Leased Premises?), contingent on a third-party tenant entering into a new lease with ARE for the Leased Premises by a specified date (the ?Lease Termination Contingency?). On September 13, 2023 (the ?Contingency Satisfaction Date?), ARE notified the Company that the Lease Termination Contingency had been satisfied under the terms of the Lease Termination Agreement.

Upon the satisfaction of the Lease Termination Contingency and pursuant to the Lease Termination Agreement, ARE agreed to pay the Company lease termination payments of (a) approximately $1.8 million within 10 business days of the Contingency Satisfaction Date, and (b) an additional amount of approximately $1.0 million within 135 days of the Contingency Satisfaction Date. In addition, ARE agreed to refund the Company approximately $1.1 million in prepaid base rent under the terms of the OAS Lease and return to the Company a letter of credit in the amount of approximately $1.1 million issued to ARE pursuant to the terms of the OAS Lease, in each case within 60 days of the Contingency Satisfaction Date. Concurrent with the Lease Termination Agreement, the Company and ARE entered into an amendment (the ?3033 Lease Amendment?) to that certain lease agreement between the parties originally signed in November 2019 (as amended, the ?3033 Lease?), pursuant to which the Company leases certain office space in San Diego, California, from ARE.

Pursuant to the 3033 Lease Amendment, upon the satisfaction of the Lease Termination Contingency, the Company agreed to extend the term of the 3033 Lease from an expected termination date of December 1, 2024, to a new termination date of October 31, 2036. In addition, ARE agreed to provide the Company with a specified tenant improvement allowance and a limited right to expand the 3033 Lease to add additional designated space if such space becomes available on specified terms pursuant to the terms of the 3033 Lease Amendment.