Forward-Looking Statements



In addition to historical information, this quarterly report on Form 10-Q
contains forward-looking statements within the meaning of Section 27A of the
Securities Act of 1933, as amended (the "Securities Act"), and Section 21E of
the Securities Exchange Act of 1934, as amended (the "Exchange Act"). These
statements include, among other things, our expectations and intentions
regarding our strategic objectives and the means to achieve them, our beliefs
and expectations regarding macroeconomic conditions, including inflation,
fluctuations in currency exchange rates, consumer confidence and demand,
weakness in general economic conditions and recessions, our expectations
regarding the near and long-term implications of the COVID-19 pandemic on the
global and regional economies, our expectations regarding the impact of the
military conflict in Ukraine generally and specifically regarding our operations
and assets in Russia, including the potential ramifications of sanctions and
regarding relations with other countries and impact on our workforce located in
Russia, our marketing and efforts to build our brand awareness, our beliefs
regarding digital dentistry and its potential to impact our business, our
intentions regarding expanding our business, our expectations regarding the
utilization rates for our products, including the impact of marketing on those
rates and causes for periodic fluctuations of the rates, our expectation
regarding customer and consumer purchasing behavior, including expectations
related to consumer demand for digital solutions, our expectations for future
investments in and benefits from sales and marketing activities, our
preparedness and our customers' preparedness to react to changing circumstances
and demand, results of operations and financial condition, our expectations for
our expenses and capital obligations and expenditures in particular, our
intentions to control spending and for investments, our intentions regarding the
investment of our international earnings from operations, our belief regarding
the sufficiency of our cash balances and borrowing capacity, our judgments
regarding the estimates used in our revenue recognition and assessment of
goodwill and intangible assets, our expectations regarding our tax positions and
the judgments we make related to our tax obligations, our predicted level of
operating expenses and gross margins and other factors beyond our control, our
expectations regarding staying in compliance with laws and regulations currently
applicable to, or which may become applicable to, our business both in the
United States and internationally, as well as other statements regarding our
future operations, financial condition and prospects and business strategies.
These statements may contain words such as "expects," "anticipates," "intends,"
"plans," "believes," "estimates," or other words indicating future results.
These forward-looking statements are subject to certain risks and uncertainties
that could cause actual results to differ materially from those reflected in the
forward-looking statements. Factors that could cause or contribute to such
differences include, but are not limited to, those discussed in Part I, Item 2
"Management's Discussion and Analysis of Financial Condition and Results of
Operations," and in particular, the risks discussed below in Part II, Item 1A
"Risk Factors." We undertake no obligation to revise or update these
forward-looking statements. Given these risks and uncertainties, readers are
cautioned not to place undue reliance on such forward-looking statements.

The following discussion and analysis of our financial condition and results of
operations should be read together with our condensed consolidated financial
statements and related notes included elsewhere in this Quarterly Report on
Form 10-Q and with our audited consolidated financial statements included in our
Annual Report on Form 10-K for the year ended December 31, 2021 as filed with
the Securities and Exchange Commission (the "SEC").

Executive Overview of Results

Trends and Uncertainties



Our business strategic priorities remain focused on four principal pillars of
growth: (i) international expansion; (ii) general practitioner dentists ("GPs")
adoption; (iii) patient demand and conversion; and (iv) orthodontic utilization.
Below is a discussion of the significant trends and uncertainties that could
impact to our operations:

Macroeconomic Challenges and Military Conflict in Ukraine



Our revenues and costs are susceptible to fluctuations in macroeconomic
conditions, in line with inflation and slowing global and regional economic
activity and contractions, changes in customer and consumer sentiment and
demand, seasonality, increasing prices for commodities, services and
transportation and disruptions in our manufacturing, supply and distribution
operations and also those of our suppliers. These factors can be further
exacerbated by the anticipation of, or actual, global and regional economic
recessions which compound the impacts of existing macroeconomic challenges.
Moreover, many of our international operations are denominated in currencies
other than the U.S. dollar and the weakening of the foreign currencies against
the U.S. dollar has caused a negative impact on our financial condition and
results of operations which we expect to continue into the future. Specifically,
during the first half of 2022, primarily due to the military conflict between
Russia and Ukraine and the significant sanctions that followed, Russia's
currency, the ruble, weakened against the U.S. dollar. The nature and extent of
the impact of these factors varies by time and region and remain uncertain and
unpredictable.

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The military conflict between Russia and Ukraine has increased the
unpredictability of the already uncertain macroeconomic conditions. We remain
deeply concerned about the devastating events that have and continue to unfold
in Ukraine and the significant humanitarian, economic and societal tragedy
unfolding there. Our top priority remains the safety and security of our
employees and their families, particularly those most directly impacted by the
hostilities and the resulting sanctions and retaliatory sanctions. We continue
to employ a significant number of research and development personnel in Russia
as well as sales, marketing and administrative personnel. We do not have
employees in Ukraine. We have taken extraordinary efforts to support our team
members in the region, including helping them financially and working to
maintain their safety and security. We furthermore accelerated programs underway
before the conflict began aimed at maintaining and growing our research and
development operations over the long run that includes diversifying the
facilities at which our personnel are located. Our Board of Directors and its
applicable committees receive regular updates from management and have and
continue to provide oversight of the risks associated with the military conflict
between Russia and Ukraine and other areas of strategic importance related to
the conflict. Our management continues to closely monitor the situation and
evaluate additional ways in which we can support our employees.

Although immaterial to our consolidated financial statements, our commercial
business operations in Russia have been significantly impacted by the conflict.
In February 2022, after the military conflict commenced, our primary shipping
vendor, UPS, ceased deliveries into Russia and shortly thereafter, we suspended
all commercial activities. Our current focus is on providing continuity of care
consistent with our values and ethical responsibility to patients, who are in
treatment. In doing so, we are also focused on managing compliance with global
sanctions applicable to our business, including significant restrictions imposed
by countries on both sides of the conflict targeting business entities, persons
and certain activities. The pace at which sanctions are being imposed and the
expanding number and breadth of the sanctions enacted continue to create global
and regional economic challenges that have caused and are expected to continue
to cause significant uncertainty and unpredictability to our operations.

COVID-19 Pandemic Update



The COVID-19 pandemic continues to cause significant volatility and uncertainty
in the global and regional economies, leading to changes in consumer and
business behavior, market fluctuations, materials and product shortages and
restrictions on business and individual activities, all of which are materially
impacting supply and demand in broad sectors of the world markets. As new
variants of the virus emerge, there has been a patchwork response to prevent its
spread and, consequently, continuing fluctuations in the numbers of patients
seeking treatment for dental services and the number of doctors providing
services and treatments in other markets. The emergence of new variants,
vaccinations and public health measures are driving the pace of economic
recovery unevenly in various regions. These factors and ongoing consumer
concerns regarding the virus have continued to impact our results of operations,
sometimes materially, and may continue to impact our results in future periods.
Therefore, comparing our financial results for the reporting periods of 2022 to
the same reporting periods of 2021 or earlier may not be a useful means by which
to evaluate the health of our business and our results of operations.

Our top priority remains the health and safety of our employees and their
families, our customers and their staff, and we are taking prudent measures to
safeguard them while remaining flexible in our operational efforts. Concerns
regarding the spread and impact of the virus have lessened in many countries in
which we operate, including the U.S. Consequently, efforts to reopen many of our
offices in 2022 are continuing but remain in fluctuation as certain parts of the
world at certain periods of time continue to respond to outbreaks of COVID-19
and new variants of the virus. Where our offices have reopened, we have adopted
a flexible hybrid schedule that will allow many of our employees the opportunity
to collaborate and connect with others in our offices three days per week while
having the option to work remotely other days. We believe that this added
flexibility benefits employees and Align overall.

Overall, we expect the challenges and risks discussed above to persist, creating
uncertainty and unpredictability for consumers, global and regional economies as
well as our business and the businesses of our customers and suppliers. We
strive to manage the challenges by focusing on improving our operations,
building flexibility and efficiencies in our processes, and adjusting our
business models to changing circumstances. Specifically, we are managing cost
impacts through pricing actions, implementing cost saving measures, and averting
supply chain shortages and delays. We do this by proactively communicating with
our suppliers and distributors and modifying our purchase order commitments to
mitigate the risks of production interruptions and maintaining inventory levels
as required. We have also increased our cybersecurity measures to detect,
protect against potential incidents and recover from actual incidents and
events.

Further discussion of the impact of the unpredictable macroeconomic conditions, the military conflict in Ukraine, and the ramifications from the impacts of COVID-19 on our business may be found in Part II, Item 1A of this Quarterly Report on Form 10-Q under the heading "Risk Factors."

Key Financial and Operating Metrics


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We measure our performance against these strategic priorities by the achievement of key financial and operating metrics.

For the three months ended June 30, 2022, our business operations reflect the following:



•Revenues of $969.6 million, a decrease of 4.1% year-over-year;
•Clear Aligner revenues of $798.4 million, a decrease of 5.1% year-over-year;
•Americas Clear Aligner revenues of $385.2 million, a decrease of 3.8%
year-over-year;
•International Clear Aligner revenues of $346.2 million, a decrease of 11.2%
year-over-year;
•Clear Aligner case volume decrease of 10.0% year-over-year and Clear Aligner
case volume decrease for teenage patients of 2.1% year-over-year;
•Imaging Systems and CAD/CAM Services revenues of $171.2 million, an increase of
0.8% year-over-year;
•Income from operations of $188.2 million and operating margin of 19.4%;
•Effective tax rate of 35.0%;
•Net income of $112.8 million with diluted net income per share of $1.44;
•Cash, cash equivalents and marketable securities of $977.2 million as of
June 30, 2022;
•Operating cash flow of $127.0 million;
•Capital expenditures of $76.0 million, predominantly related to increases in
our manufacturing capacity and facilities; and
•Number of employees was 24,020 as of June 30, 2022, an increase of 17.8%
year-over-year.

Other Statistical Data and Trends



•As of June 30, 2022, approximately 13.4 million people worldwide have been
treated with our Invisalign system, approximately 77,000 iTero scanners have
been sold and approximately 51,000 exocad software licenses have been installed.
Management measures these results by comparing to the millions of people who can
benefit from straighter teeth and dental practices that could use intraoral
scanners and uses this data to target opportunities to expand the market for
orthodontics by educating consumers about the benefits of straighter teeth using
the Invisalign system, dental professionals and/or labs and service providers to
use iTero intraoral scanners, and dental labs and practitioners to install
exocad CAD/CAM software.

•For the second quarter of 2022, total Invisalign cases submitted with a digital
scanner in the Americas increased to 91.4%, up from 86.6% in the second quarter
of 2021 and international scans increased to 84.4%, up from 76.2% in the second
quarter of 2021. For the second quarter of 2022, 97.1% of Invisalign cases
submitted by North American orthodontists were submitted digitally.

•Total utilization rate in the second quarter of 2022 decreased to 7.3 cases per doctor compared to 8.0 cases per doctor in the second quarter of 2021. Utilization rates in North America and our International locations were as follows:



?North America: Utilization rate among our North American orthodontist customers
decreased to 26.8 cases per doctor in the second quarter of 2022 compared to
29.4 cases per doctor in the second quarter of 2021 and the utilization rate
among our North American GP customers decreased to 5.1 cases per doctor in the
second quarter of 2022 compared to 5.3 cases per doctor in the second quarter of
2021.

?International: International doctor utilization rate was 6.4 cases per doctor
in the second quarter of 2022 compared to 7.1 cases per doctor in the second
quarter of 2021.
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                    [[Image Removed: algn-20220630_g1.jpg]]
* Invisalign utilization rates are calculated by the number of cases shipped
divided by the number of doctors to whom cases were shipped. Our International
region includes Europe, Middle East and Africa ("EMEA") and Asia Pacific
("APAC"). Latin America ("LATAM") is excluded from the International region
based on its immateriality to the quarter; however is included in the Total
utilization.

Results of Operations

Net Revenues by Reportable Segment

We group our operations into two reportable segments: Clear Aligner segment and Systems and Services segment.

•Our Clear Aligner segment consists of Comprehensive Products, Non-Comprehensive Products and Non-Case revenues as defined below:

?Comprehensive Products include, but are not limited to, Invisalign Comprehensive and Invisalign First.

?Non-Comprehensive Products include, but are not limited to, Invisalign Moderate, Lite and Express packages and Invisalign Go and Invisalign Go Plus.



?Non-Case products include, but are not limited to, retention products,
Invisalign training, adjusting tools used by dental professionals during the
course of treatment and, more recently, Consumer Products that are complementary
to our doctor-prescribed principal products such as aligner cases (clamshells),
teeth whitening products, cleaning solutions (crystals, foam and other material)
and other oral health products available in certain e-commerce channels in
select markets. We also offer in the U.S. and Canada, a Doctor Subscription
Program which is a monthly subscription program based on the doctor's monthly
need for retention or limited treatment. The program allows doctors the
flexibility to order both "touch-up" or retention aligners within their
subscribed tier and is designed for a segment of experienced Invisalign doctors
who are currently not regularly using our retainers or low-stage aligners.

•Our Systems and Services segment consists of our iTero intraoral scanning systems, which includes a single hardware platform and restorative or orthodontic software options. Our services include subscription software, disposables, rentals, pay per scan services, as well as exocad's CAD/CAM software solutions that integrate workflows to dental labs and dental practices.


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Net revenues for our Clear Aligner and Systems and Services segments by region
for the three and six months ended June 30, 2022 and 2021 are as follows (in
millions):
                                              Three Months Ended                                                       Six Months Ended
                                                   June 30,                                                                June 30,
Net Revenues                                2022               2021                     Change                      2022               2021                     Change
Clear Aligner net revenues:
Americas                                $   385.2          $   400.5          $ (15.3)            (3.8) %       $   761.4          $   757.9          $  3.5              0.5  %
International                               346.2              389.7            (43.5)           (11.2) %           717.3              743.0           (25.7)            (3.5) %
Non-case                                     67.0               50.8             16.2             31.9  %           129.4               93.3            36.1             38.7  %

Total Clear Aligner net revenues $ 798.4 $ 841.0

   $ (42.6)            (5.1) %       $ 1,608.1          $ 1,594.2          $ 13.9              0.9  %
Systems and Services net revenues           171.2              169.8              1.3              0.8  %           334.7              311.4            23.3              7.5  %
Total net revenues                      $   969.6          $ 1,010.8          $ (41.3)            (4.1) %       $ 1,942.8          $ 1,905.6          $ 37.2              2.0  %


Changes and percentages are based on actual values. Certain tables may not sum or recalculate due to rounding.

Case volume data which represents Clear Aligner case shipments for the three and six months ended June 30, 2022 and 2021 is as follows (in thousands):


                                        Three Months Ended                                                             Six Months Ended
                                             June 30,                                                                      June 30,
                                     2022                 2021                       Change                        2022                  2021                       Change

Total case volume                   599.0                665.6             

  (66.6)           (10.0) %          1,197.8               1,261.4               (63.6)            (5.0) %


Changes and percentages are based on actual values. Certain tables may not sum or recalculate due to rounding.



For the three months ended June 30, 2022, total net revenues decreased $41.3
million as compared to the same period in 2021 primarily due to a decrease in
Clear Aligner case volume partially offset by increases in Clear Aligner ASP,
Clear Aligner non-case revenues and service revenues.

For the six months ended June 30, 2022, total net revenues increased $37.2 million as compared to the same period in 2021 primarily due to increases in Clear Aligner ASP, Clear Aligner non-case revenues and service revenues partially offset by a decrease in Clear Aligner case volume.

Clear Aligner - Americas



For the three months ended June 30, 2022, Americas net revenues decreased by
$15.3 million as compared to the same period in 2021 primarily due to a 9.9%
decrease in case volume which reduced net revenues by $39.7 million which was
partially offset by an increase in ASP which increased net revenues by $24.4
million. Higher ASP was mainly due to processing fees charged on most clear
aligner shipments and price increases in certain markets which increased
revenues by $12.7 million along with lower net deferrals which increased net
revenues by $11.4 million.

For the six months ended June 30, 2022, Americas net revenues increased by $3.5
million as compared to the same period in 2021 primarily due to an increase in
ASP which increased net revenues by $48.5 million. Higher ASP was mainly due to
processing fees charged on most clear aligner shipments and price increases in
certain markets which increased revenues by $25.5 million along with lower net
deferrals which increased net revenues by $20.2 million. Higher ASP was
partially offset by a 5.9% decrease in case volume which reduced net revenues by
$45.0 million.

Clear Aligner - International

For the three months ended June 30, 2022, International net revenues decreased
by $43.5 million as compared to the same period in 2021 primarily due to a 10.1%
decrease in case volume which reduced net revenues by $39.5 million. Lower ASP
also decreased net revenues by $4.0 million largely due to unfavorable foreign
exchange rates which decreased net revenues by $33.4 million and a product mix
shift to lower priced products which decreased net revenues by $10.0 million.
The decrease in ASP was partially offset by lower net deferrals which increased
net revenues by $29.2 million and processing fees charged on most clear aligner
shipments which increased net revenues by $12.1 million.

For the six months ended June 30, 2022, International net revenues decreased by
$25.7 million as compared to the same period in 2021 primarily due to a 3.9%
decrease in case volume which resulted in lower net revenues of $29.3 million.
Higher
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ASP increased net revenues by $3.6 million largely due to lower net deferrals
which increased net revenues by $47.4 million and processing fees charged on
most clear aligner shipments which increased net revenues by $36.9 million. The
increase in ASP was mostly offset by unfavorable foreign exchange rates which
decreased net revenues by $56.3 million, unfavorable promotional discounts which
decreased net revenues $14.6 million, and a product mix shift to lower priced
products which decreased net revenues by $11.5 million.
Clear Aligner - Non-Case

For the three and six months ended June 30, 2022, non-case net revenues
increased by $16.2 million and $36.1 million as compared to the same periods in
2021 due to increased volume for retention products across all regions primarily
driven by Vivera retainers.

Systems and Services

For the three months ended June 30, 2022, Systems and Services net revenues
increased by $1.3 million as compared to the same period in 2021 primarily due
to higher service and other revenues which increased $18.7 million mostly due to
a larger installed base. These increases were mostly offset by a lower number of
scanners sold which decreased net revenues $13.1 million in addition to a lower
scanner ASP.

For the six months ended June 30, 2022, Systems and Services net revenues
increased by $23.3 million as compared to the same period in 2021 primarily due
to higher service and other revenues which increased $36.4 million mostly due to
a larger installed base partially offset by a lower number of scanners sold
which decreased net revenues by $9.5 million and lower scanner ASP.

Cost of net revenues and gross profit (in millions):


                                    Three Months Ended                           Six Months Ended
                                         June 30,                                    June 30,
                                    2022           2021        Change          2022            2021         Change
Clear Aligner
Cost of net revenues            $   213.2       $ 194.3       $  18.9      $   417.2       $   363.0       $  54.1
% of net segment revenues            26.7  %       23.1  %                      25.9  %         22.8  %
Gross profit                    $   585.2       $ 646.7       $ (61.4)     $ 1,190.9       $ 1,231.2       $ (40.3)
Gross margin %                       73.3  %       76.9  %                      74.1  %         77.2  %
Systems and Services
Cost of net revenues            $    68.8       $  58.0       $  10.9      $   128.7       $   106.9       $  21.8
% of net segment revenues            40.2  %       34.1  %                      38.5  %         34.3  %
Gross profit                    $   102.3       $ 111.9       $  (9.6)     $   206.0       $   204.4       $   1.5
Gross margin %                       59.8  %       65.9  %                      61.5  %         65.7  %
Total cost of net revenues      $   282.0       $ 252.3       $  29.7      $   545.9       $   469.9       $  75.9
% of net revenues                    29.1  %       25.0  %                      28.1  %         24.7  %
Gross profit                    $   687.6       $ 758.5       $ (71.0)     $ 1,396.9       $ 1,435.6       $ (38.7)
Gross margin %                       70.9  %       75.0  %                      71.9  %         75.3  %


Changes and percentages are based on actual values. Certain tables may not sum or recalculate due to rounding.



Cost of net revenues includes personnel-related costs including payroll and
stock-based compensation for staff involved in the production process, the cost
of materials, packaging, freight and shipping related costs, depreciation on
capital equipment and facilities used in the production process, amortization of
acquired intangible assets and training costs.

Clear Aligner



For the three and six months ended June 30, 2022, our gross margin percentage
decreased as compared to the same periods in 2021 primarily due to a higher mix
of additional aligners along with increased costs from freight and manufacturing
spend. These factors were offset in part by higher ASP.

Systems and Services


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For the three and six months ended June 30, 2022, our gross margin percentage
decreased as compared to the same period in 2021 primarily due to lower ASP,
manufacturing inefficiencies from lower production volumes and higher component
costs partially offset by higher service revenues.

Selling, general and administrative (in millions):


                                                 Three Months Ended                                   Six Months Ended
                                                      June 30,                                            June 30,
                                                2022              2021            Change            2022             2021            Change

Selling, general and administrative $ 426.4 $ 431.9

    $  (5.5)         $ 865.9          $ 829.0          $  36.8
% of net revenues                                44.0  %          42.7  %                           44.6  %          43.5  %


Changes and percentages are based on actual values. Certain tables may not sum or recalculate due to rounding.



Selling, general and administrative expense generally includes personnel-related
costs, including payroll, stock-based compensation and commissions for our sales
force, marketing and advertising expenses including media, market research,
marketing materials, clinical education, trade shows and industry events, legal
and outside service costs, equipment, software and maintenance costs,
depreciation and amortization expense and allocations of corporate overhead
expenses including facilities and Information Technology ("IT").

For the three months ended June 30, 2022, selling, general and administrative
expense decreased compared to the same period in 2021 primarily due to lower
advertising and marketing costs, and lower incentive compensation. These
decreases were partially offset by higher salaries expense, fringe benefits and
stock-based compensation from increased headcount along with higher equipment,
software and material costs.

For the six months ended June 30, 2022, selling, general and administrative
expense increased compared to the same period in 2021 primarily due to higher
salaries expense, fringe benefits and stock-based compensation from increased
headcount, higher expense related to advertising and marketing, equipment,
software and maintenance in addition to increased travel and expense related
costs. These increases were partially offset by lower incentive compensation.

Research and development (in millions):


                                  Three Months Ended                        Six Months Ended
                                       June 30,                                 June 30,
                                  2022           2021        Change        2022          2021        Change
Research and development      $    73.0        $ 57.7       $ 15.3      $ 144.8       $ 112.3       $ 32.5
% of net revenues                   7.5   %       5.7  %                    7.5  %        5.9  %


Changes and percentages are based on actual values. Certain tables may not sum or recalculate due to rounding.



Research and development expense generally includes personnel-related costs,
including payroll and stock-based compensation, outside service costs associated
with the research and development of new products and enhancements to existing
products, software, equipment, material and maintenance costs, depreciation and
amortization expense and allocations of corporate overhead expenses including
facilities and IT.

For the three and six months ended June 30, 2022, research and development
expense increased compared to the same periods in 2021 primarily due to higher
compensation costs from higher salaries and fringe benefits driven mainly by
increased headcount as we continue to focus our investments in innovation and
research.

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Income from operations (in millions):


                                        Three Months Ended                         Six Months Ended
                                             June 30,                                  June 30,
                                        2022           2021        Change         2022          2021         Change
Clear Aligner
Income from operations              $   307.2       $ 347.6       $ (40.4)     $ 619.9       $ 675.1       $  (55.2)
Operating margin %                       38.5  %       41.3  %                    38.6  %       42.3  %
Systems and Services
Income from operations              $    45.6       $  64.7       $ (19.1)     $  96.4       $ 111.9       $  (15.5)
Operating margin %                       26.6  %       38.1  %                    28.8  %       35.9  %
Total income from operations 1      $   188.2       $ 268.9       $ (80.7)     $ 386.3       $ 494.3       $ (108.1)
Operating margin %                       19.4  %       26.6  %                    19.9  %       25.9  %


Changes and percentages are based on actual values. Certain tables may not sum or recalculate due to rounding.

1 Refer to Note 13 "Segments and Geographical Information" of the Notes to Condensed Consolidated Financial Statements for details on unallocated corporate expenses and the reconciliation to Condensed Consolidated Income from Operations.

Clear Aligner

For the three months ended June 30, 2022, our operating margin percentage decreased compared to the same period in 2021 primarily due to lower gross margin which was partially offset by lower operating expenses as a percentage of net revenues.

For the six months ended June 30, 2022, our operating margin percentage decreased compared to the same period in 2021 primarily due to lower gross margin as well as higher operating expenses as a percentage of net revenues.

Systems and Services

For the three and six months ended June 30, 2022, our operating margin percentage decreased compared to the same periods in 2021 primarily due to lower gross margin as well as higher operating expenses as a percentage of net revenues.

Interest income (in millions):


                             Three Months Ended                          Six Months Ended
                                  June 30,                                   June 30,
                           2022                2021       Change         2022          2021       Change
Interest income        $    0.2              $ 0.4       $ (0.1)     $    0.9        $ 2.0       $ (1.1)
% of net revenues             -   %              -  %                       -   %      0.1  %


Changes and percentages are based on actual values. Certain tables may not sum or recalculate due to rounding.

Interest income generally includes interest earned on cash, cash equivalents and investment balances.

For the three months ended June 30, 2022, there was no significant change to interest income compared to the same period in 2021.



For the six months ended June 30, 2022, interest income decreased compared to
the same period in 2021 mainly due to interest earned from the arbitration award
related to our investment in SmileDirectClub in the first quarter of 2021.

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Other income (expense), net (in millions):


                                     Three Months Ended                         Six Months Ended
                                          June 30,                                  June 30,
                                     2022           2021        Change         2022          2021        Change
Other income (expense), net      $    (14.8)      $ (0.5)      $ (14.3)     $  (26.1)      $ 34.0       $ (60.2)
% of net revenues                      (1.5) %         -  %                     (1.3) %       1.8  %


Changes and percentages are based on actual values. Certain tables may not sum or recalculate due to rounding.

Other income (expense), net, generally includes foreign exchange gains and losses, gains and losses on foreign currency forward contracts, interest expense, gains and losses on equity investments and other miscellaneous charges.



For the three months ended June 30, 2022, other income (expense), net decreased
compared to the same period in 2021 primarily due to larger net foreign exchange
losses in the three months ended June 30, 2022 as compared to the same period in
2021.

For the six months ended June 30, 2022, other income (expense), net decreased
compared to the same period in 2021 primarily due to a $43.4 million gain
related to the arbitration award related to our investment in SmileDirectClub
recognized in the first quarter of 2021 as well as larger net foreign exchange
losses in the six months ended June 30, 2022 as compared to the same period in
2021.

Provision for income taxes (in millions):


                                    Three Months Ended                              Six Months Ended
                                         June 30,                                       June 30,
                                    2022           2021        Change        2022          2021        Change
Provision for income taxes      $    60.8        $ 69.1       $ (8.3)     $ 114.0       $ 130.3       $ (16.3)
Effective tax rates                  35.0   %      25.7  %                   31.6  %       24.6  %

Changes and percentages are based on actual values. Certain tables may not sum or recalculate due to rounding.



Our effective tax rate differs from the statutory federal income tax rate of 21%
for both the three and six months ended June 30, 2022 and 2021 primarily due to
the recognition of additional tax expense resulting from foreign income taxed at
different rates, state income taxes, and non-deductible expenses in the U.S.
partially offset by the recognition of excess tax benefits related to
stock-based compensation. Additionally, a change in U.S. tax laws effective
January 1, 2022 which requires capitalization and amortization of research and
development expenses incurred after December 31, 2021 increased our effective
tax rate for the three and six months ended June 30, 2022.

The increase in our effective tax rate for the three and six months ended
June 30, 2022 compared to the same periods in 2021 is primarily attributable to
foreign income taxed at different rates, capitalization and amortization of
research and development expenses in 2022 and lower excess tax benefits from
stock-based compensation.

Liquidity and Capital Resources

Liquidity and Trends



As of June 30, 2022 and December 31, 2021, we had the following cash and cash
equivalents and short-term and long-term marketable securities (in thousands):

                                        June 30, 2022       December 31, 2021
Cash and cash equivalents              $      877,501      $        1,099,370
Marketable securities, short-term              22,138                  

71,972


Marketable securities, long-term               77,551                 125,320
Total                                  $      977,190      $        1,296,662

As of June 30, 2022 and December 31, 2021, approximately $725.8 million and $713.8 million, respectively, of cash, cash equivalents and marketable securities held by our foreign subsidiaries. Our intent is to permanently reinvest our earnings from our international operations going forward, and our current plans do not require us to repatriate them to fund our U.S.


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operations as we generate sufficient domestic operating cash flow and have
access to external funding under our $300.0 million revolving line of credit. We
believe that our current cash balances and the borrowing capacity under our
credit facility, if necessary, will be sufficient to fund our business for at
least the next 12 months.

The sanctions against Russian banks or international bank messaging systems due
to the military conflict between Ukraine and Russia could impact our ability to
access our cash in Russia but would not materially impact our liquidity
position. As of June 30, 2022, cash and cash equivalents domiciled in Russia
represent approximately 7.0% of our total cash, cash equivalents and marketable
securities which is required to fund their current operating requirements.

Our material cash requirements are as follows:



•For 2022, we expect our investments in capital expenditures to exceed
$300.0 million. Capital expenditures primarily relate to building construction
and improvements as well as additional manufacturing capacity to support our
international expansion. This includes our investment in an aligner fabrication
facility in Wroclaw, Poland which began serving doctors during the second
quarter of 2022 as a part of our strategy to bring operational facilities closer
to customers. As we continue growing, we intend to expand our investments in
research and development, manufacturing, treatment planning, sales and marketing
operations to meet actual and anticipated local and regional demands.

•As of June 30, 2022, we have $449.9 million available for repurchase under the
stock repurchase program authorized by our Board of Directors in May 2021. Refer
to Note 9 "Common Stock Repurchase Program" of the Notes to Condensed
Consolidated Financial Statements for details on our stock repurchase programs.

•There have been no material changes to our purchase commitments for goods and
services and future operating lease payments during the periods covered by this
10-Q outside the normal course of business compared to the disclosures in Part
II, Item 7 of our Annual Report on Form 10-K for the year ended December 31,
2021.

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