Alnylam Pharmaceuticals, Inc. Announces Management Changes
January 03, 2017 at 04:00 pm EST
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Alnylam Pharmaceuticals, Inc. announced that David-Alexandre "DA" Gros, M.D., Senior Vice President and Chief Business Officer, plans to leave the company for personal reasons. His resignation will be effective January 6, 2017, and the company will initiate a search for his replacement. Additionally, the Company announced the promotion of Pushkal Garg, M.D., Senior Vice President, Clinical Development, to the role of Chief Medical Officer, reporting to Akshay Vaishnaw, Executive Vice President of R&D. In his promotion to Chief Medical Officer, Dr. Garg will be responsible for clinical development at Alnylam, leading clinical research, clinical operations, biometrics, and medical writing functions. He will also join the company’s Management Board. Dr. Garg joined Alnylam in late 2014 with over 15 years of experience in early and late-stage clinical drug development, including at Bristol-Myers Squibb and Millennium Pharmaceuticals.
Alnylam Pharmaceuticals, Inc. is a clinical-stage company. The Company is engaged in developing mRNA cell therapies for the treatment of autoimmune diseases. The Companyâs lead product candidate, Descartes-08, is an autologous mRNA CAR-T directed against the B cell maturation antigen (BCMA). Descartes-08 targets BCMA, which exists on the surface of long-lived plasma cells and plasmacytoid dendritic cells. Descartes-08 is in Phase IIb clinical development for patients with generalized myasthenia gravis (MG). Its other product candidate includes Descartes-15 and Descartes-33. Descartes-15 is a next-generation, autologous anti-BCMA mRNA CAR-T. Using its proprietary technology and manufacturing platform, it designed Descartes-15 to be more resistant than Descartes-08 to recycling of the CAR upon multiple antigen exposures. It is developing Descartes-33 to deliver a combination of therapeutic proteins that target key drivers in the pathogenesis of autoimmunity.
ALNYLAM PHARMACEUTICALS, INC. 
