Leading a New

Paradigm in

Preventative

Cardiovascular Care

Investor

Presentation

November 2021

Forward Looking Statements & Disclaimer

This presentation contains forward-looking statements, such as those relating to the commercial potential of VASCEPA®(VAZKEPA® in Europe), clinical and regulatory efforts and timelines, potential regulatory and pricing approvals, patent litigation, generic product launch, intellectual property, cash flow, research and development, and other statements that are forward-looking in nature and depend upon or refer to future events or conditions, including financial guidance and milestones. These statements involve known and unknown risks, uncertainties and other factors that can cause actual results to differ materially. Investors should not place undue reliance on forward-looking statements, which speak only as of the presentation date of this presentation. Please refer to the "Risk Factors" section in Amarin's most recent Forms 10 -K and 10-Q filed with the SEC and cautionary statements outlined in recent press releases for more complete descriptions of risks in an investment in Amarin.

This presentation is intended for communication with investors and not for drug promotion.

AMARIN, VASCEPA, VAZKEPA and REDUCE-IT are trademarks of Amarin Pharmaceuticals Ireland Limited. VAZKEPA is a registered trademark in Europe and other countries and regions and is pending registration in the United States.

AMARIN

2

CardiovascularDisease (CVD) Is an Enormous and Worsening Public Health Burden

US CVD BURDEN

EUROPE CVD BURDEN

INTERNATIONAL CVD BURDEN

1 stroke, heart attack

50M with CVD

523M

or death from CVD

in Europe4

living with CVD globally6

every 13 seconds in the US1

>$1.0tn

$555bn

€210bn

estimated economic

annual treatment cost expected

annual spending on CV

burden by 20307

to double in 20 years2

disease management5

38.9M

3.9M

China alone

291M with CVD & the

patients on statins3

People die each year from a

leading cause of death8

heart attack or a stroke4

Leading cause of death globally | Increasing prevalence | High and increasing economic burden

1 Heart Disease in the United States: 2020; 2 Cardiovascular Disease: A Costly Burden for America Projections Through 2035; 3 IMS Data: 2020; 4 European Heart Network Report, 2017; 5 ESC CardiovascularRealities 2020 report; 6 IMS Data 7 Global

Burden of Cardiovascular Diseases and Risk Factors, 1990-2019 - 2020 8 WEF-Harvard Global Economic Burden 9 China Cardiovascular Diseases Report2018: anupdated summary - Jan2020

AMARIN

3

Lowering LDL-C Helps But is Not Enough for Many Patients

Controlled LDL-C doesn'teliminate CV risk; P-CVR often remains 25%-35% lowering majoradverse CV events (MACE) shown in CV outcome studies of statin therapies

P-CVR - Persistent Cardiovascular Risk

LDL-C control

25-35%

Persistent risk beyond

LDL-C control

65-75%

Placebo groups from multiple recent trials show high P-CVR despite statin-basedstandard-of-care

14.6% to 34.7% of patients treated for LDL-C butnot for P-CVR experienced a major adverse cardiovascularevent(MACE) in 3-7 Years

30

IMPROVE-IT: 34.7%

of statin-treated patients

had a MACE at

%*

7 years3

20

event,

REDUCE-IT®: 28.3%

an

ith

of statin-treated patients

All statin-treated

had a MACE at

w

patients had well

Patients

5 years2

10

controlled LDL-C

levels (ranging from

67-92 mg/dL*)

FOURIER: 14.6%

of statin-treated patients

had a MACE at

3 years1

0

Years of

follow up

3

5

7

Cross-trial comparisons are subject to differences in populations, primary

outcomes, and other trial design aspects

AMARIN

Note: FOURIER, REDUCE-IT® and IMPROVE-IT trials evaluated evolocumab, icosapent ethyl and ezetimibe / simvastatin, respectively

* 67 mg/dL is equivalent to 0.8 mmol/L and 92 mg/dL is equivalent to 1.0 mmol/L

4

1. Sabatine MS, et al. N Engl J Med.2017;376(18):1713-1722; 2. BhattDL, et al; for REDUCE-IT® Investigators. N Engl J Med. 2019;380(1):11-22; 3. Cannon CP, et al. N Engl J Med. 2015;372(25):2387-2397

CV Drug Development:

A Challenging Endeavor

  • Many biopharma abandoned drug development in CV
  • Requirements for long-term outcomes studies evaluating thousands of patients take years to fulfill
  • Significant costs to fund the commercial infrastructure needed for broad primary care reach

AMARIN

Amarin:

Succeeding in a Challenging Environment

  • With REDUCE-IT®, developed the first and only approved medication for reducing cardiovascular risk beyond LDL lowering therapies in certain high-risk, statin- treated, patients
  • Received US FDA approval with unanimous Advisory committee positive vote of 16:0
  • Received European Medicines Agency (EMA) approval for a broad label in-line with the REDUCE-IT evidence

5

This is an excerpt of the original content. To continue reading it, access the original document here.

Attachments

  • Original Link
  • Original Document
  • Permalink

Disclaimer

Amarin Corporation plc published this content on 23 November 2021 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 23 November 2021 15:59:09 UTC.