As skin cells get older, their ability to divide becomes significantly weakened, slowing down the speed of regeneration and the overall functionality of skin tissue. They also lose the ability to produce collagen and elastic fibers which, in turn, slows down skin regeneration making the skin thinner, and thus creating wrinkles. In addition, a weak skin barrier causes frequent dryness, itchy skin, and other troubles.
In this industry-university research collaboration, Amorepacific R&D Center and
These findings are meaningful in that we have found the potential to reverse the biological phenomenon of aging in skin cells that was previously considered irreversible. When we regulated the activity of PDK1 (3-phosphoinositide–dependent protein kinase 1), the core factor that reverse aging, in the artificial model of aged skin, we found that PDK1 inhibition not only reverses the reduction in collagen synthesis, but also helps recover the skin's ability to regenerate. It is expected that we can leverage this reverse aging technology to not only predict and suppress the progress of age-related diseases, but also to prolong the healthy years of our lives.
Based on the results of the studies, Amorepacific R&D Center is developing cosmetics that reduce wrinkles by extracting a core ingredient in Camellia japonica seed extract that controls aging in human skin.
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SOURCE Amorepacific
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