Item 5.02. Departure of Directors or Certain Officers; Election of Directors;


           Appointment of Certain Officers; Compensatory Arrangements of Certain
           Officers

Ampio Pharmaceuticals, Inc. (the "Company") is a party to an Employment Agreement dated November 22, 2021 with Michael A. Martino pursuant to which Mr. Martino serves as the Company's Chief Executive Officer for a term ending on November 22, 2022. On August 30, 2022, the Company and Mr. Martino entered into an Amendment No. 1 to Employment Agreement, attached hereto as Exhibit 10.1, to extend the term of the Employment Agreement to November 22, 2023. No other changes were made in the terms of Mr. Martino's employment as Chief Executive Officer. The Amendment No. 1 to Employment Agreement was approved by the Compensation Committee of the Board of Directors of the Company.

Item 9.01. Financial Statements and Exhibits.




Exhibit No.     Description
10.1              Amendment No. 1 to Employment Agreement dated August 30, 2022 by
                and between Ampio Pharmaceuticals, Inc. and Michael A. Martino.
104             Cover Page Interactive Data File (formatted as Inline XBRL)

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