AngioDynamics : rsquo; Fiscal 2021 Fourth Quarter Financial Results

ANGIODYNAMICS

Fourth Quarter 2021 Earnings Presentation

July 13, 2021

1

Forward-Looking Statement

Notice Regarding Forward-LookingStatements

This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements regarding AngioDynamics' expected future financial position, results of operations, cash flows, business strategy, budgets, projected costs, capital expenditures, products, competitive positions, growth opportunities, plans and objectives of management for future operations, as well as statements that include the words such as "expects," "reaffirms," "intends," "anticipates," "plans," "projects," "believes," "seeks," "estimates," "optimistic," or variations of such words and similar expressions, are forward-looking statements. These forward-looking statements are not guarantees of future performance and are subject to risks and uncertainties. Investors are cautioned that actual events or results may differ materially from AngioDynamics' expectations, expressed or implied. Factors that may affect the actual results achieved by AngioDynamics include, without limitation, the scale and scope of the COVID-19 global pandemic, the ability of AngioDynamics to develop its existing and new products, technological advances and patents attained by competitors, infringement of AngioDynamics' technology or assertions that AngioDynamics' technology infringes the technology of third parties, the ability of AngioDynamics to effectively compete against competitors that have substantially greater resources, future actions by the FDA or other regulatory agencies, domestic and foreign health care reforms and government regulations, results of pending or future clinical trials, overall economic conditions, the results of on-going litigation, challenges with respect to third-party distributors or joint venture partners or collaborators, the results of sales efforts, the effects of product recalls and product liability claims, changes in key personnel, the ability of AngioDynamics to execute on strategic initiatives, the effects of economic, credit and capital market conditions, general market conditions, market acceptance, foreign currency exchange rate fluctuations, the effects on pricing from group purchasing organizations and competition, the ability of AngioDynamics to integrate acquired businesses, as well as the risk factors listed from time to time in AngioDynamics' SEC filings, including but not limited to its Annual Report on Form 10-K for the year ended May 31, 2020. AngioDynamics does not assume any obligation to publicly update or revise any forward-looking statements for any reason.

In the United States, the NanoKnife System has received a 510(k) clearance by the Food and Drug Administration for use in the surgical ablation of soft tissue, and is similarly approved for commercialization in Canada, the European Union and Australia. The NanoKnife System has not been cleared for the treatment or therapy of a specific disease or condition.

Notice Regarding Non-GAAP FinancialMeasures

Management uses non-GAAP measures to establish operational goals and believes that non-GAAP measures may assist investors in analyzing the underlying trends in AngioDynamics' business over time. Investors should consider these non- GAAP measures in addition to, not as a substitute for or as superior to, financial reporting measures prepared in accordance with GAAP. In this presentation, AngioDynamics has reported adjusted EBITDA (income before interest, taxes, depreciation and amortization and stock-based compensation); adjusted net income and adjusted earnings per share. Management uses these measures in its internal analysis and review of operational performance. Management believes that these measures provide investors with useful information in comparing AngioDynamics' performance over different periods. By using these non-GAAP measures, management believes that investors get a better picture of the performance of AngioDynamics' underlying business. Management encourages investors to review AngioDynamics' financial results prepared in accordance with GAAP to understand AngioDynamics' performance taking into account all relevant factors, including those that may only occur from time to time but have a material impact on AngioDynamics' financial results. Please see the tables that follow for a reconciliation of non-GAAP measures to measures prepared in accordance with GAAP.

2

Corporate Developments - Q4 Highlights

• Continued focused investment in our 3 key technology platforms: Auryon, AngioVac & NanoKnife

• YOY comparisons are significantly impacted by the COVID-19 global pandemic
• Procedural volumes continued to rebound in Q4
• AngioVac cases continued their sequential quarterly growth
• • 108% growth in AngioVac YOY
  • $4.6 million in Auryon sales
  • NanoKnife disposable growth: US 69% YOY; worldwide growth of 42% YOY
  • • NanoKnife DIRECT study: 26 active sites
    • Encouraged by the overall execution of the study in the current environment
    • • Received FDA clearance for the AlphaVac Mechanical Thrombectomy System subsequent to quarter end
      • Received approval for NanoKnife prostate IDE (PRESERVE) subsequent to quarter end

• Completed enrollment of PATHFINDER 1 pilot registry

• Shifting our focus to the pivotal study phase

• $14.0 million write-off of the OARtrac intangible assets
• • Reduced debt outstanding under the revolver to $20.0 million as of May 31, 2021

FY22 Guidance

Revenue	Gross Margin	Adjusted EPS
$305 - $310 million	~55%	$0.00 - $0.05	3

Fourth Quarter and FY2021 Highlights

Financial Performance

	Q4 FY2021	Q4 FY2020	YOY
$ in thousands (except per share data)	Change
Revenue	$76,842	$58,332	31.7%
Gross Margin	55.1%	51.8%	330 bps
Net Loss	($19,468)	($157,067)	$137,599
GAAP EPS	($0.51)	($4.13)	$3.62
Adjusted EPS	$0.00	($0.06)	$0.06
Adjusted EBITDA	$4,512	$553	$3,959

Product Family Sales Growth Over Prior Year Periods

Endovascular Therapies (formerly VIT)	Q4 FY2021	FY2021
AngioVac®	108%	47%
Auryon	NA*	NA*
Thrombolytic	(36%)	(11%)
Core Peripheral	47%	9%
Venous Insufficiency	85%	0%

Vascular Access	Q4 FY2021	FY2021
Midlines	(2%)	28%
C3	110%	NA**
PICCs	(10%)	8%
Ports	26%	5%
Dialysis	(3%)	1%

Oncology	Q4 FY2021	FY2021
NanoKnife® Capital	(77%)	(48%)
NanoKnife® Disposables	42%	13%
Solero® Microwave	38%	11%
BioSentry	93%	38%
Alatus and IsoLoc Balloons	6%	(18%)
RadioFrequency Ablation	(10%)	(21%)	4
* The Auryon full market launch took place in the second quarter of fiscal year 2021.
** The C3 Wave acquisition took place in December 2019.

Fourth Quarter and FY2021 Highlights

Sales Growth Over Prior Year Periods - Additional Detail

Med Tech	Q4 FY2021	FY2021
Auryon	NA**	NA**
Mechanical Thrombectomy*	62%	32%
NanoKnife® Disposables	42%	13%
NanoKnife® Capital	(77%)	(48%)

Med Device	Q4 FY2021	FY2021
Solero® Microwave	38%	11%
BioSentry	93%	38%
Core Peripheral	47%	9%
Venous Insufficiency	85%	0%
Alatus and IsoLoc Balloons	6%	(18%)
RadioFrequency Ablation	(10%)	(21%)
Midlines	(2%)	28%
C3	110%	NA***
PICCs	(10%)	8%
Ports	26%	5%
Dialysis	(3%)	1%

* Mechanical Thrombectomy comprises AngioVac and Thrombolytics.
** The Auryon full market launch took place in the second quarter of fiscal year 2021.
*** The C3 Wave acquisition took place in December 2019.	5