Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

On February 1, 2022, Ricky Sun, Ph.D., notified the Board of Directors (the "Board") of Annexon, Inc. (the "Company") of his decision to resign from the Board, effective immediately. Dr. Sun's resignation was not a result of any disagreement with the Company or any matter relating to the Company's operations, policies or practices.

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