On November 10, 2021, Graphite Bio, Inc. (the ?Company?) and Annexon, Inc. (the ?Sublandlord?) entered into a sublease agreement (the ?Sublease?) for office and laboratory space (the ?Premises?). The Premises consist of 18,326 square feet located at 1400 Sierra Point Parkway, Brisbane, California. In connection with its use of the Premises, the Company will also have the non-exclusive right to use a portion of the premises in the building consisting of 3,645 square feet of space leased by the Sublandlord from the master landlord. The term of the Sublease is expected to commence, subject to certain conditions, on or before December 1, 2021 (the ?Commencement Date?). The Sublease has a term of 24 months from the Commencement Date (the ?Term?), subject to earlier termination (i) by the Company in the event Sublease term has not commenced by January 1, 2022 or (ii) upon any termination of the master lease under which Sublandlord has leased the Premises from the master landlord. Under the Sublease, the Company is obligated to pay a base rent of $139,470.06 per month during the first twelve months of the Term and $144,351.51 per month for the remaining twelve months of the Term. The Company is also obligated to pay to the Sublandlord a pro-rated portion, as set forth in the Sublease, of certain direct expenses and the costs of utilities under the Sublandlord?s master lease with the master landlord. In addition, the Company has agreed to pay to the Sublandlord all costs of the Sublandlord incurred for performing any repairs or maintenance or providing other services to the Premises or the shared space specifically requested by the Company.