Antengene Corporation Limited announced that it will present the preclinical data on the synergistic effect of the combination of XPO1 and mTORC1/2 inhibition for the treatment of triple-hit diffuse large B-cell lymphoma (DLBCL) at the American Association for Cancer Research (AACR) Annual Meeting 2021, which will be held in a virtual format on April 10-15 and May 17-21, 2021. Covering the most cutting-edge advances and regarded globally as the very pinnacle of cancer research, the AACR Annual Meeting is one of the largest and most anticipated scientific events in the cancer research field globally. The abstract entitled "Synergistic effect of the combination of XPO1 and mTORC1/2 inhibition for the treatment of triple-hit DLBCL" now available on the AACR's website, is the first publication from the preclinical study investigating ATG-010 (XPO1 inhibitor) and ATG-008 (mTORC1/2 inhibitor). ATG-010, also known as selinexor, is the world's first approved selective inhibitor of the nuclear export protein XPO1. ATG-010 induces the apoptosis of cancer cells in vitro and in vivo through the targeted inhibition of the nuclear export protein XPO1 that leads to the nuclear storage and activation of tumor-suppressor proteins and other growth-regulating proteins, and by down-regulating the intracytoplasmic levels of various oncogenic proteins without affecting normal cells. ATG-008, also known as onatasertib, is a next-generation dual mTORC1/2 inhibitor. mTORC1 and mTORC2 are critical mediators of the PI3K-AKT pathway, which is commonly mutated in many cancers, thus leading to the hyperactivation of mTOR signaling. ATG-008 could reduce the proliferation and promote the apoptosis of tumor cells through the dual-inhibition of mTORC1 and mTORC2. ATG-008, also known as onatasertib, is a next-generation dual mTORC1/2 inhibitor. mTORC1 and mTORC2 are critical mediators of the PI3K-AKT pathway, which is commonly mutated in many cancers, thus leading to the hyperactivation of mTOR signaling. ATG-008 could reduce the proliferation and promote the apoptosis of tumor cells through the dual-inhibition of mTORC1 and mTORC2. At present, Antengene is conducting several trials of ATG-010 in China for the treatment of MM, DLBCL, non-small cell lung cancer (NSCLC), endometrial cancer, peripheral T-cell lymphoma.