Admedus Limited announced the commencement of a preclinical study that will compare anti-calcification properties of its proprietary ADAPT® treated tissue with other bovine and porcine tissues that are used currently in commercially available SAVR and TAVR valves. Calcification plays a significant role in the failure of bioprosthetic and other tissue heart valve substitutes. The study will be conducted in Minneapolis, USA at a world-renowned preclinical facility. The aim of this study is to evaluate anti-calcification properties in the established subcutaneous rat model. Forty-eight (48) rats will be implanted. Harvested implants will be processed for histological and calcium/phosphorus analysis initially at the end of four months.