Item 5.07. Submission of Matters to a Vote of Security Holders.

At the 2022 Annual Meeting of Stockholders (the "Annual Meeting") held on June 2, 2022, the stockholders of Applied Therapeutics, Inc. (the "Company") voted on the matters described below.

1. The Company's stockholders elected two Class III directors, who comprise all


    the directors of such class, to serve until the 2025 Annual Meeting of
    Stockholders and until her successor is duly elected and qualified or until
    her earlier death, resignation or removal. The numbers of shares that voted
    for the election of such directors, withheld authority to vote for such
    directors and represented broker non-votes with respect to this proposal are
    summarized in the table below.

Director Nominee Votes For Votes Withheld Broker Non-Votes Shoshana Shendelman, Ph.D. 12,816,619 3,897,920 4,961,777 Teena Lerner, Ph.D. 12,857,167 3,857,372 4,961,777

2. The Company's stockholders ratified the appointment of Ernst & Young LLP as


    the Company's independent registered public accounting firm for the fiscal
    year ending December 31, 2022. The numbers of shares that voted for, against
    and abstained from voting for or against the ratification of the appointment
    of Ernst & Young LLP are summarized in the table below.



Votes For    Votes Against   Abstentions
21,650,444      25,740           132

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