Item 5.07 Submission of Matters to a Vote of Security Holders

Aptinyx Inc. (the "Company") held its Annual Meeting of Stockholders on May 26, 2022. The following is a summary of the matters voted on at that meeting.





   a) The stockholders of the Company elected Gilmore O'Neill, M.B., M.M.Sc.,
      Norbert G. Riedel, Ph.D. and Rachel E. Sherman, M.D., M.P.H. as class I
      directors, for a three-year term ending at the annual meeting of
      stockholders to be held in 2025 and until their successor has been duly
      elected and qualified or until their earlier resignation or removal. The
      results of the stockholders' vote with respect to the election of the class
      I directors were as follows:




                       Votes            Votes           Broker
Name                    For           Withheld        Non-Votes
Gilmore O'Neill       36,961,638        219,745        15,257,941
Norbert G. Riedel     34,306,879       2,874,504       15,257,941
Rachel E. Sherman     34,371,182       2,810,201       15,257,941




   b) The stockholders of the Company ratified the selection of Deloitte & Touche
      LLP as the Company's independent registered public accounting firm for the
      fiscal year ending December 31, 2022. The results of the stockholders' vote
      with respect to such ratification were as follows:




 Votes For        Votes Against      Abstain
  52,302,426           59,461          77,437

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