Item 8.01. Other Events.

On September 16, 2021, ARCA biopharma, Inc. ("ARCA") provided an ASPEN-COVID-19 Phase 2b clinical trial update. The press release is furnished as Exhibit 99.1 hereto, the contents of which are incorporated herein by reference.

Item 9.01. Financial Statements and Exhibits.



(d) Exhibits.




Exhibit Number          Description

99.1                      Press Release titled "ARCA biopharma Announces Enrollment
                        of First International Patient in Phase 2b Clinical Trial
                        Evaluating rNAPc2 as a Potential Treatment for COVID-19"
                        dated September 16, 2021  .
104                     Cover Page Interactive Data File. The cover page XBRL tags
                        are embedded within the inline XBRL document (contained in
                        Exhibit 101).











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