Item 8.01. Other Events.

On October 28, 2021, ARCA biopharma, Inc. ("ARCA") provided an ASPEN-COVID-19 Phase 2b clinical trial update. The press release is furnished as Exhibit 99.1 hereto, the contents of which are incorporated herein by reference.

Item 9.01. Financial Statements and Exhibits.



(d) Exhibits.




Exhibit Number          Description

99.1                      Press Release titled "ASPEN-COVID-19 Data and Safety
                        Monitoring Committee Recommends Continuing Phase 2b
                        Clinical Trial to Completion Based on Interim Analysis of
                        Efficacy and Safety Data" dated October 28, 2021  .
104                     Cover Page Interactive Data File. The cover page XBRL tags
                        are embedded within the inline XBRL document (contained in
                        Exhibit 101).

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