argenx SE announced it will regain worldwide rights to its anti-CD70 antibody cusatuzumab from Cilag GmbH International, one of the Janssen Pharmaceutical Companies of Johnson & Johnson. Interim data from the Phase 1b ELEVATE trial support continued development in acute myeloid leukemia (AML) and argenx plans to evaluate options to enable a path forward. The ongoing Phase 1b ELEVATE trial is evaluating cusatuzumab in combination with venetoclax and azacitidine in newly-diagnosed, elderly patients with AML. The intent-to-treat (ITT) population included 44 patients. Early efficacy analyses conducted in all evaluable patients (N=42) after ongoing patients had completed at least two disease evaluations showed: Complete remission (CR) was observed in 48% (20/42), composite complete remission (CRc) including CRs with incomplete hematologic recovery was observed in 81% (34/42), and overall response rate (ORR) in 93% (39/42) of the evaluable population. Cusatuzumab was observed to be well-tolerated and the safety profile was consistent with prior studies. ELEVATE is ongoing; complete results will be presented in an upcoming peer-reviewed forum. Additionally, ongoing translational research on AML patient bone marrow samples from the Phase 2 CULMINATE trial show a decrease in primitive, monocytic-like blasts and leukemic stem cells, and an increase in normal myeloid cells, following treatment with cusatuzumab and azacitidine.