Artelo Biosciences, Inc. announced publication of pre-clinical results indicating a novel fatty acid binding protein 5 (FABP5) inhibitor from the Company's FABP inhibitor platform reduces anxiety behaviors in an area of the brain known to be important in anxiety and that modulation of the FABP5 system may serve as a promising target for the development of novel anxiolytics. This research, with one of many of Artelo's FABP inhibitors, which was led by Taygun C. Uzuneser, Ph.D., and Steven R. Laviolette, Ph.D., both of the University of Western Ontario, London, Ontario, was published in the journal Cerebral Cortex. Another researcher involved in the study was Iwao Ojima, Ph.D., University Distinguished Professor at Stony Brook University and the principal inventor of the multiple FABP inhibitors exclusively licensed to Artelo, including the Company's lead FABP inhibitor ART26.12 being developed as a potential treatment for Chemotherapy Induced Peripheral Neuropathy.

FABPs are a family of intracellular proteins that chaperones lipids including endocannabinoids and fatty acids. Inhibitors of FABPs are intended for treatment of cancer, neuropathic and nociceptive pain, and anxiety. Artelo licensed multiple compounds through its collaboration with Stony Brook University.

The Company's lead compound, ART26.12, is a selective inhibitor of FABP5. Artelo's near-term goal is to develop ART26.12 for the prevention and/or treatment of Chemotherapy Induced Peripheral Neuropathies, for which there are no regulatory approved medicines. While progressing the lead FABP inhibitor in regulatory-enabling studies, additional compound(s) have been identified and selected for advancement in anxiety-related disorders, including Post-Traumatic Stress Disorder.