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ASCENDIS PHARMA A/S

(ASND)
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Ascendis Pharma A/S Announces Presentations for TransCon PTH and TransCon CNP at the American Society for Bone & Mineral Research 2021 Annual Meeting

09/30/2021 | 04:01pm EST

Ascendis Pharma A/S announced presentations featuring new data about its investigational TransCon PTH product candidate at the American Society for Bone & Mineral Research (ASBMR) 2021 Annual Meeting, being held October 1-4 virtually and in-person in San Diego. Presentations will also include an overview of baseline demographics from the Ascendis Pharma-sponsored natural history study of children with achondroplasia. Hypoparathyroidism (HP) is a rare endocrine disorder characterized by insufficient levels of parathyroid hormone (PTH) which plays a critical role in controlling systemic calcium, phosphate, and calcitriol (active vitamin D) levels and is essential to many key biological functions. HP affects approximately 400,000 patients in the United States, Europe, Japan, South Korea and Greater China, the majority of whom develop the condition following damage or accidental removal of the parathyroid glands during thyroid surgery. Patients often experience decreased quality of life. In the short term, symptoms include weakness, severe muscle cramps (tetany), abnormal sensations such as tingling, burning and numbness (paresthesia), memory loss, impaired judgment and headache. Over the long term, this complex disorder can increase risk of major complications, such as extraskeletal calcium depositions occurring within the brain, lens of the eye, and kidneys, which can lead to impaired renal function. HP remains among the few hormonal insufficiency states without an approved replacement therapy that restores the missing hormone at physiologic levels. Standard of care with active vitamin D analogs and calcium supplementation does not fully control the disease and may contribute to risk of renal disease. As a result, patients with HP have an estimated 4-fold to 8-fold greater risk of renal disease compared to healthy controls.


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Financials
Sales 2021 7,69 M 8,71 M 8,71 M
Net income 2021 -401 M -454 M -454 M
Net cash 2021 677 M 766 M 766 M
P/E ratio 2021 -17,0x
Yield 2021 -
Capitalization 6 866 M 7 772 M 7 770 M
EV / Sales 2021 804x
EV / Sales 2022 90,4x
Nbr of Employees 482
Free-Float 10,5%
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Number of Analysts 12
Last Close Price 125,12 €
Average target price 171,04 €
Spread / Average Target 36,7%
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Managers and Directors
Jan M°ller Mikkelsen President, CEO & Executive Director
Scott Thomas Smith Chief Financial Officer & Senior Vice President
Albert Cha Chairman
Birgitte Volck SVP, Head-Clinical Development & Medical Affairs
Kennett Sprog°e Senior Vice President, Head-Innovation & Research
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