PARIS, April 8 (Reuters) - France's top health body will on
Friday say that recipients of a first dose of AstraZeneca's
traditional COVID-19 vaccine who are under 55 should get
a second shot with a new-style messenger-RNA vaccine, two
sources aware of the plans said on Thursday.
Reuters had reported on Wednesday that the Haute Autorite de
la Sante (HAS), in charge of setting out how vaccines approved
by the European Medicines Agency (EMA) should be used in France,
was contemplating this possibility.
The HAS has now decided to proceed with the plan, the two
sources said. Two mRNA vaccines, one from Pfizer and
BioNTech and one from Moderna, are approved
for use in France.
Messenger RNA vaccines prompt the human body to make a
protein that mimics part of the virus, triggering an immune
response, while traditional vaccines such as AstraZeneca's use
an inactivated virus to carry a protein from the pathogen - in
this case the novel coronavirus - to do the same thing.
An HAS spokeswoman had no comment.
Vaccination programmes have stuttered in Europe and
elsewhere in the last month, since a very few mostly young
recipients of the AstraZeneca shot were found to have suffered
extremely unusual blood clots, leading some countries to suspend
its use as a precaution.
Most have resumed using the shot, although some have done so
with age restrictions.
In France, the HAS advised on March 19 that only people aged
55 and over should receive the AstraZeneca vaccine, which had
already been given to 500,000 people as a first dose.
While the numbers are small compared with the tens of
millions being inoculated across the EU, a decision to give a
different booster shot would be significant because the approach
has not been tested in late-stage human trials.
Germany was the first European country to recommend that
people under 60 who have had a first AstraZeneca shot should
receive a different product for their second dose.
Some experts say that, because all the vaccines target the
same outer "spike" protein of the virus, they could be
complementary. But there is no evidence that this approach will
be as effective.
(Reporting by Matthias Blamont; Editing by Kevin Liffey)