First medicine targeting BRCA mutations to show clinical benefit in adjuvant setting
Lynparza is being jointly developed and commercialised by
The
Breast cancer is now the most diagnosed cancer worldwide with an estimated 2.3 million patients diagnosed in 2020.2 Nearly 91% of all breast cancer patients are diagnosed at an early stage of disease and BRCA mutations are found in approximately 5% of patients.3,4,5
The sNDA was based on results from the OlympiA Phase III trial presented during the 2021
These results showed Lynparza demonstrated a statistically significant and clinically meaningful improvement in invasive disease-free survival (iDFS), reducing the risk of invasive breast cancer recurrence, second cancers or death by 42% versus placebo (based on a hazard ratio of 0.58; 99.5% confidence interval 0.41-0.82; p
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(C) 2021 M2 COMMUNICATIONS, source