An investigational cancer drug has been shown to help regenerate damaged nerves after spinal trauma with "remarkable recovery" of sensory and motor functions in animals, British scientists say.
The researchers said they used cell and animal models to demonstrate that oral treatment with a cancer candidate drug -- known as AZD1390 and manufactured by
This, investigators from the
"Our findings show a remarkable recovery of sensory and motor functions, and AZD1390-treated animals being indistinguishable from uninjured animals within four weeks of injury,"
The persistent activation of the body's DNA damage response system may prevent recovery from spinal cord injury, Ahmed noted. So, he said, blocking it with a drug such as AZD1390 could promote nerve repair and help restore function after injury.
Ahmed is also lead for the neuroscience and ophthalmology section in the
The scientists said they anticipate a swift timeline toward further research and practical application of their initial findings.
"At this stage it is not yet a medicine," Ahmed told UPI in an email. "However, candidate drugs have already satisfied demanding and specific criteria, and with the right level of funding it could be taken through clinical trials quickly."
He added: "If successful it could be available for patient use within five to seven years."
Ahmed's colleague,
AZD1390, described as a potent, "brain-penetrating" ataxia telangiectasia mutant kinase inhibitor, is under investigation in a federally funded, multi-center phase 1 trial in
The drug also has investigational status in
In the new study, the researchers first found that AZD1390 stimulated nerve cell growth in culture, and inhibited the ATM protein kinase pathway that regulates the response to DNA damage, according to the news release.
Next they used animal models to investigate the effect of AZD1390 following spinal cord injury and found that oral treatment with the drug "resulted in significant suppression of the ATM protein kinase pathway, nerve regeneration beyond the site of injury, and the ability of these nerves to carry electrical signals across the site of the injury."
The program is described as sharing compounds, tools, technologies and expertise with the scientific community to advance drug discovery and development.
In May, the scientists published a study in the same journal on another AztraZeneca drug, AZD1236, which they found may significantly reduce "secondary damage" after spinal trauma by blocking the inflammatory response in the spinal cord.
That study also was funded by
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