Certain Common Stock of Avenue Therapeutics, Inc. are subject to a Lock-Up Agreement Ending on 24-DEC-2021. These Common Stock will be under lockup for 45 days starting from 9-NOV-2021 to 24-DEC-2021. Details: The executive officers and directors have agreed that they will not offer, sell, contract to sell, pledge or otherwise dispose of, directly or indirectly, any shares of common stock or securities convertible into or exchangeable or exercisable for any shares of common stock, for a period of 45 days from the date of the final prospectus supplement without the prior written consent of representative.