AxoGen : Corporate Presentation

Corporate presentation

January 9, 2023

nasdaq: axgn

Safe harbor statement

This presentation contains "forward-looking" statements as defined in the Private Securities Litigation Reform Act of 1995. These statements are based on management's current expectations or predictions of future conditions, events, or results based on various assumptions and management's estimates of trends and economic factors in the markets in which we are active, as well as our business plans. Words such as "expects," "anticipates," "intends," "plans," "believes," "seeks," "estimates," "projects," "forecasts," "continue," "may," "should," "will," "goals," and variations of such words and similar expressions are intended to identify such forward-looking statements. Forward-looking statements include (1) foundation for long-term sustainable growth, (2) TAM for the targeted nerve markets, (3) our preliminary, unaudited fourth quarter and full year 2022 financial results, (4) our preliminary topline results from Recon study, (5) timing of our submission of our BLA for Avance® Nerve Graft in the second half of the year, and (6) timing of our transitioning to our new processing facility in Dayton, OH in the first half of 2023. Actual results or events could differ materially from those described in any forward- looking statements as a result of various factors, including,

without limitation, statements related to the impact of COVID- 19 on our business, including but not limited to global supply chain issues, hospital staffing challenges and its impact on our business, recessionary pressures, inflation, interest rate increases, market awareness and adoption of our products, anticipated capital requirements, including the potential of future financings, data validation, expected clinical study enrollment, timing and outcomes, our visibility at and sponsorship of conferences and our educational events, regulatory process and approvals, legislative, regulatory, political, geopolitical, and economic developments, as well as those risk factors described under Part I, Item 1A., "Risk Factors," of our Annual Report on Form 10-K for the most recently ended fiscal year. Forward-looking statements are not a guarantee of future performance, and actual results may differ materially from those projected. The forward-looking statements are representative only as of the date they are made and, except as required by applicable law, we assume no responsibility to publicly update or revise any forward- looking statements.

revolutionizing the science of nerve repair®	2

The Axogen platform for nerve repair

revolutionizing the science of nerve repair®	3

The function of nerves

Nerves are like wires

• Transfer signals across a network
• If cut, data cannot be transferred
• If crushed, short circuits and data corruption may occur

The peripheral nervous system is a vast network from every organ to and from the brain

• Sensory
• Motor
• Autonomic

Nerves can be injured in three ways:

1. Transection

Traumatic nerve injuries e.g., motor vehicle accidents, power tool accidents, battlefield injuries, gunshot wounds, surgical injuries, neuroma-in- continuity

2. Compression

Carpal, cubital, tarsal tunnel revisions, blunt trauma, previous surgeries

3. Stump Neuroma

Amputations, mastectomies, previous surgeries

revolutionizing the science of nerve repair®	4

A comprehensive platform for addressing nerve injuries

Connection

revolutionizing the science of nerve repair®

Protection

Termination

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