Industry 4.0, or the fourth industrial revolution, refers to the automation and digitalization of traditional industrial processes through smart technology and integration.
Within this concept, a 'smart factory' is characterized by machines which are interconnected, and interoperable, and can process data autonomously. Such 'smart factories' require only limited human decision-making or intervention and are therefore sometimes referred to as 'intelligent automation.'
Innovation and operational excellence are two important pillars of
WHY ARE WE AUTOMATING AND DIGITALIZING SPPS AT
Optimizing production is crucial to us to help and support our customers in their drug development and manufacturing processes. We have started our journey to Industry 4.0 by automating and digitalizing one of our core business processes, the solid phase peptide synthesis (SPPS).
We have automated our SPPS process so that operations can be carried out with minimal human intervention, thus improving the reliability of the process, reproducibility of results and safety, while significantly increasing the cost-effectiveness of operations. Thanks to automation, we are able to optimize equipment utilization and reduce operating times and personnel time down to a fraction. This reduction enables a higher capacity, efficiency and agility of production and brings more flexibility to take on new projects.
OUR PROCESS INNOVATIONS
As first steps towards our 'smart factory', we have introduced some major innovations. The first
Another innovative feature of this new fully automated SPPS process is Process Analytical Technology (PAT), which performs inline analytics after key steps. PAT removes the need for manual In-Process Controls (IPC) and provides a better control of Critical Process Parameters (CPP). Additionally, this automated process enables data recording and analytics as well as paper-free cGMP documentation. Implementing PAT to our process control decreases human contributions and cost of goods. Indeed, manual tasks are no longer required and frees resources for other tasks and projects. Furthermore, PAT leads to a higher reproducibility with minimized chemical side reactions. Ultimately, we utilize our assets more efficiently and streamline our production scheduling for a higher capacity and flexibility.
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Tel: +41 58 595 2021
Fax: +41 58 595 2040
Email: sales.ch@bachem.com
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