BeyondSpring : Plinabulin 106 phase 3 topline data

PROTECTIVE-2 Phase 3 Registration Trial Topline Data

Plinabulin + Pegfilgrastim vs. Pegfilgrastim

November 2020 | Nasdaq: BYSI

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Disclaimer

• This presentation has been prepared for informational purposes only. No money or other consideration is being solicited, and if sent in response, will not be accepted. This presentation shall not constitute an offer to sell, or the solicitation of an offer to buy, any securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. The Company is not under any obligation to make an offering. It may choose to make an offering to some, but not all, of the people who indicate an interest in investing. The information included in any registration statement will be more complete than the information the Company is providing now, and could differ in important ways.
• This presentation and any accompanying oral commentary contain forward-looking statements about BeyondSpring Inc. ("BeyondSpring" or the "Company"). Forward- looking statements are based on our management's beliefs and assumptions and on information currently available to our management, including those described in the forward-looking statements and risk factors sections of the Company's 20-F filed on April 30, 2020 and other filings with the United States Securities and Exchange Commission (SEC).
• Such statements are subject to known and unknown risks, uncertainties, and other factors that may cause our or our industry's actual results, levels of activity, performance, or achievements to be materially different from those anticipated by such statements. In some cases, you can identify forward-looking statements by terminology such as
  "may," "will," "should," "expects," "plans," "anticipates," "believes," "estimates," "predicts," "potential," "intends," or "continue," or the negative of these terms or other comparable terminology. Forward-looking statements contained in this presentation include, but are not limited to, (i) statements regarding the timing of anticipated clinical trials for our product candidates and our research and development programs; (ii) the timing of receipt of clinical data for our product candidates; (iii) our expectations regarding the potential safety, efficacy, or clinical utility of our product candidates; (iv) the size of patient populations targeted by our product candidates and market adoption of our product candidates by physicians and patients; and (v) the timing or likelihood of regulatory filings and approvals.
• Except as required by law, we assume no obligation to update these forward-looking statements publicly, or to update the reasons why actual results could differ materially from those anticipated in the forward-looking statements, even if new information becomes available in the future。
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Plinabulin: first-in-class agent, stimulating innate and adaptive immune system

GEF-H1 activation2

Plinabulin1

Microtubules

Kill cancer

cells4

Dendritic cell maturation2,3

Kill cancer cells2

T cell activation2,3

Rho/ROCK activation1

Neutrophil demargination7

JNK activation2

Tissue level

IL-6 activation2

Increase LSK cells;	Delay neutrophil
Accelerate neutrophil maturation5	apoptosis6

Plinabulin's immune mechanism designed to enable its effects in multiple cancer indications:

• Chemotherapy Induced Neutropenia (CIN): Designed to protect progenitor cells from chemo assault in bone marrow with week 1 benefit, which compliments G-CSFweek 2 benefit for improved benefit potential
• NSCLC: Chemo (e.g. docetaxel) introduces real time tumor antigen, Plinabulin is designed to mature DC, leading to T cell activation, and durable anti-cancer benefit
• Multiple Cancer Indications: Triple combo combines "tumor antigen generation" from chemo/radiation, plinabulin "adding T cell gas", and PD-1/PD-L1"release the brake" for potential maximum durable anti- cancer benefit

Note: 1 La Sala et al., 2019 Chem. 2 Kashyap et al., 2019 Cell Reports. 3 Zhang et al., 2005 Mol Cell Biol. 4 Singh et al., 2011 Blood. 5 Suwa et al., 2000 Am J Physiol Heart Circ Physiol; Ghosh et al., 2018 ACR Annual Conference; Blayney et al., Society of Leukocyte Biology. 6 Asensi et al., 2004 Infection and Immunity.

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Breakthrough Therapy Designation

Plinabulin + G-CSF

in Chemotherapy-Induced Neutropenia (CIN)

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