Item 5.02 Departure of Directors or Certain Officers; Election of Directors;


           Appointment of Certain Officers; Compensatory Arrangements of Certain
           Officers.

On April 7, 2021, Kate Bingham notified the Chairman of the Board of Directors (the "Board") of Bicycle Therapeutics plc (the "Company") that she does not desire to seek re-election to the Board upon expiration of her current term of service as a Class II director of the Company, and that, therefore, she will retire from the Board at the close of the Company's next annual general meeting of shareholders, which is scheduled for June 28, 2021. Ms. Bingham's decision not to seek re-election and to retire from the Board is not due to any disagreement with the Company on any matter relating to the Company's operations, policies or practices.

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