Item 5.02. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

On September 9, 2022, BioCryst Pharmaceuticals, Inc. (the "Company") approved certain changes to its Leadership Team. Effective September 15, 2022, William P. Sheridan, MBBS, will serve as Chief Development Officer of the Company. Dr. Sheridan has served as the Company's Chief Medical Officer since joining the Company in July 2008, and in his new role, he will focus on advancing the Company's significant pipeline of development candidates.

Also effective September 15, 2022, Dr. Ryan Arnold will serve as the Company's new Chief Medical Officer. He has served as Senior Vice President, Global Medical Affairs of the Company since March 2022 and has more than 20 years of industry experience, including prior roles with increasing levels of responsibility in the medical affairs function at multiple companies.

Dr. Arnold joins Dr. Sheridan and Dr. Helen Thackray, the Company's Chief Research and Development Officer, as physicians on the Company's Leadership Team.

Item 7.01. Regulation FD Disclosure.

On September 14, 2022, the Company issued a press release announcing the events described in Item 5.02 of this Current Report on Form 8-K. A copy of the press release is furnished as Exhibit 99.1 hereto and is incorporated by reference herein.

The information in this Item 7.01 shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference into any filing made by the Company under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such filing.

Item 9.01. Financial Statements and Exhibits.



(d) Exhibits

Exhibit No.    Description

                 Press release dated September 14, 2022 entitled "BioCryst Names
  99.1         Dr. Bill Sheridan Chief Development Officer and Appoints Dr. Ryan
               Arnold Chief Medical Officer"
104            Cover Page Interactive Data File (embedded within the Inline XBRL
               document)

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