- MS PATHS data indicate that 100 percent of people with MS treated with natalizumab, interferons or fumarates achieved an antibody response following COVID-19 vaccination
- Data from this analysis also suggest that approximately 40 percent of people with MS treated with anti-CD20 and S1P disease-modifying therapies (DMT) mount an antibody response to the COVID-19 vaccine
- Collaborative MS PATHS network enabled rapid collection of data in the COVID-19 environment
Using data from the MS PATHS network in the
“These results demonstrate that MS DMTs impact antibody responses to COVID-19 vaccination in different ways and understanding these differences is crucial,” said
Approximately 92 percent of participants in the analysis received an mRNA vaccine. Immune response was measured using immunoglobulin G (IgG) assays. Specific IgG rates (IgG index >1) from initial post-vaccination testing (28-90 days post last vaccination dose) were 40 percent (32/80) for anti-CD20s (ocrelizumab, rituximab and ofatumumab), 41 percent (16/39) for S1P therapies (fingolimod, ozanimod, and siponimod) and 100 percent (175/175) for all other DMTs (fumarates – dimethyl-fumarate and diroximel fumarate, glatiramer acetate, interferons – IM IFN beta-1a, pegylated IFN beta-1a and IFN beta-1b, natalizumab, teriflunomide and alemtuzumab).
“We care deeply about people with MS and wanted them and their health care providers to have timely information to help address key questions about COVID-19,” said
Additional Data Presentations Featured at ECTRIMS
Biogen is presenting a total of 38 abstracts from across its MS portfolio as part of its ongoing commitment to improving the understanding of the disease and advancing treatment through innovation. Presentations at ECTRIMS include:
- IgG Immune Response to SARS-CoV-2 Vaccination in People Living With Multiple Sclerosis Within MS PATHS (P652)
- Flushing and Flushing-Related Adverse Events With Diroximel Fumarate in Patients With Relapsing-Remitting Multiple Sclerosis: Results from the Phase 3 EVOLVE-MS-2 Study (P673)
- Early Data Suggest Diroximel Fumarate Has High Rates of Real-World Adherence and Persistence (P850)
- Diroximel Fumarate in Patients With Relapsing-Remitting Multiple Sclerosis: Interim Safety and Efficacy Results from the Phase 3 EVOLVE-MS-1 Study (P739)
- Comparison of Time to Clinically Meaningful Improvement in Neuro-QoL in Patients Treated With Natalizumab Versus Ocrelizumab (P252)
- Comparison of Pharmacokinetic Profiles and Safety Outcomes with Peginterferon Beta-1a Administration in Black/African American and White Participants (P663)
- Efficacy and Safety of Opicinumab in Participants With Relapsing Multiple Sclerosis: A Randomized, Placebo-Controlled, Phase 2 Trial (AFFINITY Part 1) (P147)
About MS PATHS
Biogen sponsored the MS PATHS (Partners Advancing Technology and
About Biogen
At Biogen, our mission is clear: we are pioneers in neuroscience. Biogen discovers, develops and delivers worldwide innovative therapies for people living with serious neurological and neurodegenerative diseases as well as related therapeutic adjacencies. One of the world’s first global biotechnology companies, Biogen was founded in 1978 by
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Biogen Safe Harbor
This news release contains forward-looking statements, including statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, relating to the results of certain real-world data; the identification and treatment of MS and the effect of our therapies in relation to COVID-19 vaccination; and our research and development program for the treatment of MS. These forward-looking statements may be identified by words such as “aim,” “anticipate,” “believe,” “could,” “estimate,” “expect,” “forecast,” “goal,” “intend,” “may,” “plan,” “possible,” “potential,” “will,” “would” and other words and terms of similar meaning. Drug development and commercialization involve a high degree of risk, and only a small number of research and development programs result in commercialization of a product. Results in early stage clinical trials may not be indicative of full results or results from later stage or larger scale clinical trials and do not ensure regulatory approval. You should not place undue reliance on these statements or the scientific data presented.
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