On October 29, 2021, Andrea Acosta, the Group Vice President, Chief Accounting Officer, and principal accounting officer of BioMarin Pharmaceutical Inc. notified BioMarin of her decision to resign, effective as of January 28, 2022, in order to pursue another career opportunity. Brian Mueller, BioMarin's Executive Vice President, Finance and Chief Financial Officer, will serve as the company's principal accounting officer from the effective date until Ms. Acosta's successor is appointed. Mr. Mueller will continue to serve as BioMarin's Executive Vice President, Finance and Chief Financial Officer.