“The results from our study support using DiviTum®TKa to monitor efficacy during treatment and predict response to palbociclib, a standard therapy for women with metastatic breast cancer. It is interesting to learn that DiviTum®TKa can identify progression many months ahead of imaging,” said
The current study examines the capability of DiviTum®TKa to be an early predictor of treatment efficacy, and also as a tool for serial monitoring of women with metastatic breast cancer. The study tests a new dosing schedule of a CDK 4/6 inhibitor (palbociclib) and uses DiviTum®TKa to predict response of the therapy. Serum samples were collected pre-treatment and during therapy from 51 patients.
Results show that patients with a tumor response or no disease progression as their best response had significantly lower DiviTum®TKa values at baseline than patients with progressive disease as their best response. During serial monitoring a rise in thymidine kinase activity (TKa) was a predictor of disease progression more than three months prior to imaging progression. The study investigators conclude that serum TKa levels at baseline and on-therapy dynamics show promise for response prediction and monitoring of palbociclib therapy.
“One of our original hypotheses with the DiviTum®TKa test was that TKa levels would be a strong predictor of the treatment effect of cell cycle regulating therapies. In examining the relationship between TKa and treatment with a CDK 4/6 inhibitor, we see strong clinical data that supports that hypothesis. We are very appreciative of the work done by the investigators and their patients to further advance the science.” said
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