“We appreciate our collaboration with SWOG and are glad to see the study presented at the world´s leading breast cancer conference. The results from this large data set are highly encouraging and significantly expand the evidence base for DiviTumTKa. The data supports the intended use of DiviTumTKa as submitted for FDA approval, but also introduces a new possible prediction capability. We look forward to providing DiviTum®TKa for the benefit of patients with metastatic breast cancer,” said
In the study, DiviTum®TKa was used to analyze over 1700 samples from more than 400 patients from the start of treatment and at four different timepoints during care. Large differences were observed in median progression free survival (11 vs. 17 months) and overall survival (30 vs. 58 months) between patients with high vs. low DiviTum® TKa baseline values. These differences were maintained at each of the treatment serial monitoring timepoints.
The study also showed that for patients without prior endocrine treatment and high DiviTum® TKa values, overall survival was significantly longer for patients treated with combination endocrine treatment vs. monotherapy. This supports a predictive capacity of DiviTum®TKa when selecting therapy for metastatic breast cancer patients.
“Our study demonstrates that measuring TK activity provides important information when evaluating and selecting therapy for patients with metastatic breast cancer. The results from this large data set support previous findings that DiviTum®TKa provides accurate prognosis and monitoring of progression free survival and overall survival for these patients. We look forward to continue our collaboration with
The study is the largest study to evaluate DiviTumTKa for prognostic and serial monitoring of metastatic breast cancer. The study is the foundation of the DiviTum®TKa clinical validation submitted to the FDA on
New DiviTum®TKa results from the SWOG study will be presented at the San Antonio Breast Cancer Symposium,
SWOG Cancer Research Network
SWOG is part of the National Cancer Institute’s (NCI) National Clinical Trials Network and the NCI Community Oncology Research Program, and is part of the oldest and largest publicly-funded cancer research network in
This news release uses data that will be presented at the San Antonio Breast Cancer Symposium obtained from the S0226 study and does not necessarily reflect the opinions or views of SWOG or the NCI.
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