Item 5.07. Submission of Matters to a Vote of Security Holders.

Blueprint Medicines Corporation (the "Company") held its annual meeting of stockholders on June 2, 2021. The following is a summary of the matters voted on at the meeting.

The Company's stockholders elected George D. Demetri, M.D. and Lynn Seely,

M.D. as Class III directors, each to serve for a three-year term expiring at

1. the 2024 annual meeting of stockholders and until his or her successor has


    been duly elected and qualified. The results of the stockholders' vote with
    respect to the election of such Class III directors were as follows:



                        Votes For    Votes Withheld   Broker Non-Votes

George D. Demetri, M.D. 26,328,404 26,147,330 1,944,554 Lynn Seely, M.D. 37,134,769 15,340,965 1,944,554

The Company's stockholders approved the non-binding, advisory vote on the

2. compensation paid to its named executive officers. The results of the


    stockholders' non-binding, advisory vote with respect to compensation paid to
    the Company's named executive officers were as follows:



Votes For    Votes Against   Votes Abstaining   Broker Non-Votes
51,256,830     1,208,065          10,839           1,944,554

The Company's stockholders ratified the appointment of Ernst & Young LLP as

3. the Company's independent registered public accounting for the fiscal year


    ending December 31, 2021. The results of the stockholders' vote with respect
    to such ratification were as follows:



Votes For    Votes Against   Votes Abstaining
54,266,939      140,283           13,066




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