Botanix Pharmaceuticals Limited provided a development update on its BTX 1204A study in canines with atopic dermatitis, as well as a general update on its dermatology focused clinical and business development activities. BTX 1204A canine study now underway: Botanix announced its BTX 1204A POC study in canines with atopic dermatitis is now underway with receipt of ethics approval and initiation of sites in Australia and New Zealand. The updated study design now plans to enrol 45 canines across 3 dermatology sites which will evaluate two formulations of BTX 1204A (high dose and low dose) and a vehicle arm (15 dogs each). Each subject will be treated twice daily with topically applied BTX 1204A over a 28-day period. The study objective will be to evaluate treatment effectiveness, using the Enhanced Pruritus Score (EPS) and Canine Atopic Dermatitis Extent and Severity Index (CADESI-04). Atopic dermatitis in canines and humans is clinically and immunologically very similar. Successful outcomes from the BTX 1204A POC study will drive licensing programs for animal health and also support progression to a late-stage Phase 2b clinical study in humans with atopic dermatitis. The potential benefit of BTX 1204A in canine and human atopic dermatitis is supported by studies that indicate synthetic CBD addresses multiple factors of disease pathology, inhibits itch and repairs skin barrier dysfunction, is a potent antimicrobial against Staph Aureus bacteria, and has broad anti-inflammatory properties. There is significant unmet need for an effective, safe and topically applied therapeutic to treat atopic dermatitis. In the US alone, approximately 31 million people have a form of the disease, with 1 in 10 people in the general population developing symptoms during their lifetime. BTX 1702 rosacea study progressing well: Botanix advised that recruitment for its BTX 1702 Phase 1b rosacea study is progressing to plan, despite COVID-19 restrictions in some of the areas where clinic sites have been selected. Recruitment for clinical studies is considered "essential work" under the respective States' guidelines and additional sites have been screened to maintain recruitment momentum if required in future. The BTX 1702 Phase 1b rosacea study is a randomised, double blind, vehicle-controlled study in patients with moderate to severe papulopustular rosacea. The study is investigating the safety and tolerability of two different concentrations of BTX 1702 and a vehicle (placebo) arm in adults, over an 8-week treatment period. The study plans to enrol approximately 120 patients in dermatology clinical sites across Australia and New Zealand.