PRESS RELEASE : BRAIN Biotech AG: Genome Editing Tool Developed by BRAIN

DGAP-News: BRAIN Biotech AG / Key word(s): Miscellaneous 
BRAIN Biotech AG: Genome Editing Tool Developed by BRAIN 
2021-05-06 / 18:00 
The issuer is solely responsible for the content of this announcement. 
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Zwingenberg, Germany, May 6^th, 2021 
Genome Editing Tool Developed by BRAIN 
- Novel CRISPR Cas system 
- Holding significant economic potential 
- Different commercialization models currently being explored 
BRAIN Biotech AG has successfully completed the first development phase for a novel genome editing CRISPR Cas system 
applying its advanced metagenomics sequencing and protein engineering capabilities. BRAIN's technology enabled by a 
novel and independent Non-CAS9-Nuclease will significantly speed up in-house developments and promises significant 
economic upside. 
Genome editing has lately become one of the most exciting technologies in biotechnology. It allows for the directed and 
precise insertion, deletion or modification in the genome of a living organism. The CRISPR-CAS system has provided a 
genetic tool with speed as well as simplicity that was previously unavailable to science. 
BRAIN has developed a novel CRISPR Cas tool using metagenomics sequencing and protein engineering to isolate a Non-Cas9 
genome editing nuclease. Our scientist have achieved this breakthrough employing their expertise and practical R&D 
experience with genome editing knowledge available throughout the BRAIN Group. 
BRAIN's novel CRISPR associated nuclease has been validated internally as well as with partners and it has demonstrated 
DNA targeting activity in selected bacteria, fungi and yeast. Activity in plants has been achieved but still needs to 
be validated. Genome editing tests for additional application fields such as mammalian cell lines have been initiated 
and a first IP application to protect our nuclease sequence is already submitted. 
Dr. Michael Krohn, Head R&D at BRAIN Biotech AG emphasizes: "The market for genome editing tools based on the CRISPR 
Cas mechanism is just emerging and offers significant growth opportunities. Our BRAIN developed CRISPR associated 
nuclease will give us internal freedom to operate and we are currently exploring its potential beyond microorganisms 
and plants. This success is further evidence of our stated mission to create Breakthroughs. It makes me very proud that 
the innovative spirit of our scientists keeps creating new projects with real breakthrough potential." 
Adriaan Moelker, CEO BRAIN Biotech AG, comments: "We have stated in the past that we have several projects beyond the 
feasaibility phase with significant economic potential which might reach maturity to enter our BRAIN Incubator. This 
project does exactly that. Our BRAIN developed CRISP associated nuclease will enable us to speed up projects for our 
customers as well as the internal development of high efficiency producer strains. Our next step is to explore and 
develop appropriate business models to commercialize this exciting technology." 
Lukas Linnig, CFO BRAIN Biotech AG, says: " We are very pleased by what we have already achieved and currently explore 
the best business model to further accelerate the development of this exciting genome editing tool. We aim to balance 
time too market, fields of application, investment requirements and potential partnering with the best interest of our 
shareholders for value creation." 
 
Disclaimer 
This press release contains forward-looking statements. These statements reflect the current views, expectations, and 
assumptions of the management of BRAIN Biotech AG, and are based on information currently available to the management. 
Forward-looking statements are no guarantees of future performance, and entail both known and unknown risks as well as 
uncertainties that could cause actual results, performance or events to differ materially from those expressed or 
implied in such statements. Numerous factors exist that could influence the future performance by, and future 
developments at, BRAIN Biotech AG and the BRAIN Group. Such factors include, but are not limited to, changes in the 
general economic and competitive environment, risks associated with capital markets, currency exchange rate 
fluctuations, changes in international and national laws and regulations, in particular with respect to tax laws and 
regulations, as well as other factors. 
BRAIN Biotech AG does not undertake any obligation to update or revise any forward-looking statements. 
 
About BRAIN 
BRAIN Biotech AG ("BRAIN") is a leading European specialist in industrial biotechnology. As a technology provider and 
developer of bio-based products and solutions for nutrition, health and the environment, the company supports the 
biologization of industry and contributes to a more sustainable economy. BRAIN is the parent company of the BRAIN 
Group. Two pillars form BRAIN Group's business: The BioScience segment includes contract research for renowned 
industrial partners as well as an incubator for the development of the company's own highly innovative products. In the 
BioIndustrial segment, the company focuses on specialty business in the production and refinement of enzymes, 
microorganisms and bioactive natural products and the respective distribution. 
The BRAIN Group maintains its own diverse collection of natural resources: the BRAIN Bioarchive comprises 
microorganisms, genetic material and natural substances. Based on this collection and with a comprehensive technology 
portfolio, BRAIN addresses technological challenges and develops bio-based products and solutions that are already 
successfully employed in the industry. The BRAIN Group has its own production facilities in Germany, UK and the US, 
which together with the associated biotechnological production expertise, complete the value chain within the Group. 
Since its IPO in 2016, BRAIN Biotech AG has been listed in the Prime Standard of the Frankfurt Stock Exchange (ISIN 
DE0005203947 / WKN 520394). 
 
Contact Investor Relations 
Michael Schneiders 
Head of Investor Relations & Sustainability 
Phone: [phone] 
Email: [e-mail] 
Media Contact 
Dr. Stephanie Konle 
PR & Corporate Communications 
Phone: [phone] 
Email: [e-mail] 
 
Follow BRAIN Biotech on Twitter (@BRAINbiotech) and on LinkedIn (@BRAIN AG) 
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2021-05-06 Dissemination of a Corporate News, transmitted by DGAP - a service of EQS Group AG. 
The issuer is solely responsible for the content of this announcement. 
The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. 
Archive at www.dgap.de 
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Language:     English 
Company:      BRAIN Biotech AG 
              Darmstädter Straße 34-36 
              64673 Zwingenberg 
              Germany 
Phone:        [phone] / 9331-0 
Fax:          [phone] / 9331-11 
E-mail:       [e-mail] 
Internet:     www.brain-biotech.com 
ISIN:         DE0005203947 
WKN:          520394 
Listed:       Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, 
              Hamburg, Munich, Stuttgart, Tradegate Exchange 
EQS News ID:  1193626 
 
End of News   DGAP News Service 
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1193626 2021-05-06

 
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May 06, 2021 12:01 ET (16:01 GMT)