Roquette, BRAIN AG, and BRAIN Group company AnalytiCon Discovery have successfully completed the R&D phase for the development of Brazzein. The partners have now signed a contractual agreement for its approval and production. Brazzein is a protein sweetener which is naturally found in African berries Pentadiplandra brazzeana Baillon. This high intensive sweetener provides an outstanding sweetening potency still preserving taste profile and sugar free functionality. As part of their newly agreed Joint Development Agreement (JDA), Roquette and BRAIN, will now progress with the approval and industrial scale-up of the protein sweetener in the food and beverage sector. Roquette and BRAIN, who first came together during the DOLCE research program and subsequently decided to further develop this sweetener by fermentation, see very good commercial opportunities for this compound, primarily in the beverage industry. In preparation for the upcoming production phase, BRAIN has already established a highly potent GRAS (Generally Recognized As Safe) microorganism for the biotechnological production of the sweetener. GRAS strains are well suited for the approval for the food and beverage sector, and BRAIN has already produced the sweetener at laboratory scale with commercially viable yields.