The call by Xavier Bertrand, a former minister who now leads the Hauts-de-France region, adds pressure on the government to prevent an outright closure of the facility, as the coronavirus pandemic batters confidence.
The Japanese tyre maker's announcement on Wednesday that it planned to close the Bethune plant, which employs 863 workers in Bertrand's northern region, drew swift government condemnation.
Labour Minister Elisabeth Borne is expected to visit the factory on Monday.
Bertrand, a conservative who served as health minister between 2005 and 2007 in the government of Nicolas Sarkozy, told Europe 1 radio "everything must be done" to avoid a closure - invoking a 2013 precedent in which Italy invested in a Bridgestone plant to avert closure and save 60% of its jobs.
Bertrand also stepped up his criticism of Macron in a separate interview with Le Parisien, declaring himself "more determined than ever" to challenge France's centrist incumbent in the next presidential election.
(Reporting by Tangi Salaun and Laurence Frost; Editing by Alex Richardson)