Oral presentation to highlight preclinical data demonstrating robust antiepileptic activity for darigabat in drug-resistant focal epilepsy
Poster presentations to include further evidence of tavapadon’s consistent pharmacokinetic and pharmacodynamic profile
“The collective data we are presenting at AAN 2022 represent the tremendous progress we are making with our differentiated pipeline of neuroscience drug candidates. We are particularly encouraged by the preclinical data our team is sharing, demonstrating the robust antiepileptic activity of darigabat in a model of drug-resistant focal seizures, as it further supports our belief in darigabat’s potential as a transformative medication for millions of epilepsy patients,” said
Data Highlights:
Darigabat: Darigabat is an α2/3/5-selective GABAA receptor positive allosteric modulator (PAM) currently under development for anxiety and epilepsy.
In an oral presentation, Cerevel will discuss preclinical data for darigabat that demonstrates robust antiepileptic activity in a model of drug-resistant focal seizures. Treatment with darigabat resulted in a dose-dependent reduction in spontaneous and recurrent hippocampal paroxysmal discharges (an objective biomarker of focal seizures), demonstrating comparable antiepileptic activity to diazepam at doses of 3 and 10 mg/kg.
In a separate poster presentation, Cerevel will review a study describing the successful implementation of novel data capture measures used during the COVID-19 pandemic to ensure data integrity in the ongoing Phase 2 trial of darigabat in patients with focal epilepsy.
Tavapadon: Tavapadon is a highly selective D1/D5 partial agonist currently in Phase 3 trials for the treatment of both early- and late-stage Parkinson’s disease.
Cerevel will present data demonstrating consistent clinical pharmacology across a wide range of doses of tavapadon in several Phase 1 clinical trials, supporting its potential as a promising next-generation treatment for Parkinson’s disease.
Cerevel will also present a study characterizing medication utilization among Parkinson’s disease patients prescribed levodopa or dopamine agonist treatments. The results show that levodopa treatment occurs more consistently than dopamine agonist treatment, as patients prescribed dopamine agonists had relatively high treatment modification and discontinuation rates and low medication adherence.
Presentation Details:
Oral Presentation:
Title: Pronounced Antiepileptic Activity of Darigabat, a Subtype-Selective GABAA Receptor Positive Allosteric Modulator, in the Mesial Temporal Lobe Model of Drug-Resistant Focal Epilepsy
Session: S13: Epilepsy/Clinical Neurophysiology (EEG): Antiseizure Medications
Presenting Author:
Date & Time:
Poster Presentations:
Title: Ensuring the Continuity of Data Collection in a Focal Epilepsy Clinical Trial During the COVID-19 Pandemic
Session: P2: Epilepsy/Clinical Neurophysiology (EEG): COVID 19 and Others 1
Presenting Author
Date & Time:
Title: Levodopa and Dopamine Agonist Medication Utilization among Patients with Parkinson's Disease Enrolled in Commercial and Medicare Advantage Part D Health Plans
Session: P7: Movement Disorders: PD Therapeutics 1
Presenting Author:
Date & Time:
Title: Pharmacokinetics, Pharmacodynamics, and Safety of the Highly Selective Dopamine D1/D5 Agonist Tavapadon: Summary of Phase 1 Clinical Studies
Session: P10: Movement Disorders: Trials 2
Presenting Author:
Date & Time:
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