Charles River Laboratories International, Inc. and Flagship’s Pioneering Medicines Enter Agreement Leveraging Ai-Powered Logica with Aim of Creating Novel Therapies for Unmet Medical Needs
Charles River Laboratories International, Inc. announced a multi-program agreement with Pioneering Medicines, a strategic initiative of Pioneering, that gives Pioneering Medicines access to Logica™. Logica is an Artificial Intelligence (AI) powered drug solution that translates biological insights into optimized preclinical assets by leveraging Valo Health's AI-powered Opal Computational Platform and Charles River's leading preclinical expertise. Through the agreement, Pioneering Medicines will deploy Logica across a portfolio of targets with the aim of creating optimized small molecules that lead to novel therapies for unmet medical needs.
In 2022, Charles River and Valo Health, Inc. (“Valo”) launched Logica, leveraging Valo's AI-powered Opal Computational Platform and Charles River's leading preclinical expertise, providing clients with transformed drug discovery with a single integrated offering seamlessly translating targets to candidate nomination. Logica utilizes predictive models, chemical design and synthesis capabilities, DNA-encoded libraries, in silico high throughput screening from Valo's Opal Computational Platform as well as Charles River's leading capabilities in all aspects of discovery optimization including high throughput screening, medicinal chemistry, ADME, biology, pharmacology, and ultimately safety testing and IND submission, joining together for the first time to create a computation-powered, unified target-to-candidate offering. Logica is offered as a fully managed, risk-sharing model, with most of the client cost tied to success.
Charles River Laboratories International, Inc. specializes in the development of products and services in the field of research and non-clinical drug development for pharmaceutical companies, government agencies and academic institutions. Net sales break down by activity as follows:
- discovery and safety assessment services (59.8%): discovery services for the identification, screening and selection of main compounds for the development of new drug candidates, and in vivo and in vitro testing, including pharmacokinetic, bioanalytical, metabolic, toxicological and pathological studies, for the safety assessment of pharmaceutical products, medical devices, animal health products, chemical and agrochemical products and biocides;
- development and sale of research models and related services (21.1%): mice, rats, immunodeficient models, rabbits, guinea pigs, hamsters, etc. The group also offers primary cells and specialized products (bioconservation products, freezing media for cell cultures, antigens, peptides, humanized mouse models, etc.) for the development and manufacture of new cell therapies ;
- development of solutions used in drug manufacturing processes (19.1%): products and services for microbiological testing, in vitro testing, endotoxin testing, microbial identification, development, manufacturing of avian vaccines, etc. The group also offers contract manufacturing services for cell and gene therapies.
Net sales break down by source of income between sales of services (80.9%) and sales of products (19.1%).
Net sales are distributed geographically as follows: the United States (53.3%), Europe (27.5%), Canada (12.5%), Asia/Pacific (5.1%), and other (1.6%).
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Charles River Laboratories International, Inc. and Flagship’s Pioneering Medicines Enter Agreement Leveraging Ai-Powered Logica with Aim of Creating Novel Therapies for Unmet Medical Needs
