Item 1.01 Entry into a Material Definitive Agreement

On August 26, 2020, ChemoCentryx, Inc. (the "Company") entered into a Commercial Manufacturing Agreement (the "Agreement") with Hovione LLC ("Hovione") for the manufacture and supply of the active pharmaceutical ingredient ("API") for avacopan.

Pursuant to the Agreement, the Company's purchase of avacopan API is subject to certain binding forecasting periods. The Company is also obligated to purchase from Hovione a substantial portion of the Company's requirements for avacopan API for a certain initial period of time. If avacopan is approved by the U.S. Food and Drug Administration ("FDA") or by the European Medicines Agency ("EMA"), the Company would have certain minimum annual purchase commitments for avacopan API.

The Agreement has an initial term that expires seven years after the first regulatory approval of avacopan by the FDA or EMA. The Agreement will automatically renew for successive two-year renewal terms unless either party delivers a notice of nonrenewal at least twelve months before the expiration of the initial term or the then current renewal term, as applicable.

The Agreement may be terminated by either party following an uncured material breach by the other party within 30 days of written notice of such material breach, or in the event the other party becomes insolvent or subject to bankruptcy proceedings. In addition, subject to certain termination fees, the Company may terminate the Agreement for convenience upon twelve months' prior written notice, or upon occurrence of certain regulatory events or actions, including if the Company fails to obtain approval for avacopan by the FDA or EMA, or such approval is withdrawn.

The Agreement contains representations, warranties and indemnity obligations customary for agreements of this type.

The foregoing description of the terms of the Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the Agreement, which will be filed with the Company's Quarterly Report on Form 10-Q for the quarter ending on September 30, 2020. The Company intends to redact certain confidential portions of the Agreement because such confidential portions (i) are not material and (ii) would be competitively harmful if publicly disclosed.

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