The antibody cocktail combining two virus neutralizing antibodies, casirivimab and imdevimab, was created by Regeneron for the potential treatment and prevention of COVID-19.
The casirivimab and imdevimab antibody cocktail is currently being studied globally in a phase II/III clinical study for the treatment of patients with COVID-19 who require hospitalization, a phase II/III clinical study for the treatment of non-hospitalized patients with COVID-19, and a phase III clinical study for prevention of infection in COVID-19 household contacts. A phase III open-label clinical study for the treatment of patients with COVID-19 who require hospitalization is also ongoing in the
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About casirivimab and imdevimab
Casirivimab and imdevimab were designed specifically by Regeneron scientists to block the infectivity of SARS-CoV-2, the virus that causes COVID-19. They evaluated thousands of fully-human antibodies produced by the company's proprietary VelocImmune mice, which have been genetically-modified to have a human immune system, as well as antibodies identified from humans who have recovered from COVID-19. The two potent, virus-neutralizing antibodies administered together, bind non-competitively to the critical receptor binding domain of the virus's spike protein, which may help diminish the ability of mutant viruses to escape treatment and protects against spike variants that have arisen in the human population1.
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Email: pr@chugai-pharm.co.jp
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