Item 1.01 Entry into a Material Definitive Agreement

On December 1, 2020, Cogent Biosciences, Inc. (the "Company") entered into an underwriting agreement ("Underwriting Agreement") with Jefferies LLC and Piper Sandler & Co., as the representatives of the underwriters named therein (the "Underwriters"), to issue and sell 10,256,411 shares of the Company's common stock at a public offering price of $9.75 per share (the "Offering"). In addition, the Company granted the underwriters a 30-day option to purchase up to an additional 1,538,461 shares of its common stock on the same terms and conditions (the "Option"). The gross proceeds from the offering are expected to be approximately $100.0 million before deducting customary underwriting discounts, offering expenses and excluding any exercise of the underwriters' option.

The securities described above are offered pursuant to a shelf registration statement (File No. 333-230678),which became effective on May 1, 2019. A final prospectus supplement dated December 1, 2020 relating to and describing the terms of the offering was filed with the U.S. Securities and Exchange Commission (the "SEC") on December 2, 2020.

In the Underwriting Agreement, the Company agreed to indemnify the underwriters against certain liabilities, including liabilities under the Securities Act of 1933, as amended, or to contribute payments that the underwriters may be required to make because of such liabilities.

A copy of the Underwriting Agreement is attached as Exhibit 1.1 hereto and is incorporated herein by reference. The foregoing description of the Underwriting Agreement does not purport to be complete and is qualified in its entirety by reference to such exhibit.

A copy of the opinion of Gibson, Dunn & Crutcher LLP relating to the validity of the securities issued in the Offering is filed herewith as Exhibit 5.1.

Item 8.01 Other Events.

Reference is made to the Company's prospectus dated May 1, 2019 covering the offering, issuance and sale of up to a maximum aggregate offering price of $50,000,000 (the "Maximum Offering Price") of the Company's common stock that may be issued and sold under a sales agreement with Cowen and Company, LLC (the "ATM Facility"). Prior to the execution of the Underwriting Agreement (see Item 1.01 above), the Company filed a prospectus supplement dated December 1, 2020 to reduce the Maximum Offering Price to $9,500,000. As of the date of this report, no shares have been sold under the ATM Facility.

Item 9.01 Financial Statements and Exhibits.



(d) Exhibits



 Exhibit
   No.     Description

  1.1        Cogent Biosciences, Inc. Underwriting Agreement

  5.1        Opinion of Gibson, Dunn & Crutcher LLP

 23.1        Consent of Gibson, Dunn & Crutcher LLP (included in Exhibit 5.1)

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