CTX-471 is supplied by Compass, which is also the sponsor of this study, and KEYTRUDA will be supplied by
'We are very pleased to be making progress on our CTX-471 clinical program with dosing of the first patient in the combination arm with KEYTRUDA,' said
CTX-471 is a next generation, CD137 agonist, fully human, IgG4, with optimized affinity for an agonistic antibody. It binds to a unique, membrane proximal epitope of the CD137 receptor, leading to enhanced activation of T-Cells and NK Cells. CTX-471 has completed a Phase 1 dose escalation and cohort expansion study, where it was shown to be well-tolerated. The Phase 1b monotherapy study is fully enrolled and ongoing. In this study, CTX-471 has been evaluated as a monotherapy treatment in patients with advanced solid tumors who received at least one checkpoint inhibitor post progression. As of
ClinicalTrials.gov Identifier: NCT03881488
KEYTRUDA is a registered trademark of
About
Forward-Looking Statements
This press release contains forward-looking statements. Statements in this press release that are not purely historical are forward-looking statements. Such forward-looking statements include, among other things, references to Compass's product candidate, CTX-471, its development, regulatory plans with respect thereto and therapeutic potential thereof. Actual results could differ from those projected in any forward-looking statements due to numerous factors. Such factors include, among others, Compass's ability to raise the additional funding it will need to continue to pursue its business and product development plans, the inherent uncertainties associated with developing product candidates and operating as a development stage company, Compass's ability to identify additional product candidates for development, Compass's ability to develop, complete clinical trials for, obtain approvals for and commercialize any of its product candidates, competition in the industry in which Compass operates and market conditions. These forward-looking statements are made as of the date of this press release, and Compass assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those projected in the forward-looking statements, except as required by law. Investors should consult all of the information set forth herein and should also refer to the risk factor disclosure set forth in the reports and other documents Compass files with the
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