Dublin - Cosmo Pharmaceuticals N.V. (SIX: COPN) announced today that it has expanded its existing license agreement with Dr. Falk Pharma Gmbh ('Dr. Falk') to include Rifamycin SV MMX in the new 600mg formulation currently tested in the IBS-D indication.

Under the agreement with Dr Falk, Cosmo will receive a further EUR2m down-payment plus reimbursement of a portion of the expenses borne for the development of the 600mg formulation plus a supply price which incorporates a high double-digit percentage of sales. Dr. Falk will also bear a portion of the future costs for the ongoing developments.

Rifamycin SV MMX 200mg is already approved in the US and EU for the treatment of travelers' diarrhea and it is licensed to Dr. Falk for the EU and other countries and is marketed under the brand name Relafalk, whereas it is licensed to RedHill BioPharma Ltd. (NASDAQ: RDHL) for the US where it is marketed under the brand name Aemcolo. A Phase II clinical study with Rifamycin 600mg in IBS-D indication is currently ongoing and results are expected by year end.

Rifamycin SV MMX is a pharmaceutical product containing rifamycin SV formulated with Cosmo's MMX technology. Rifamycin SV MMX contains a broad spectrum, semi-synthetic, orally non-absorbable antibiotic. The application of MMX technology to rifamycin SV allows the antibiotic to be delivered directly into the colon, avoiding unwanted effects on the beneficial bacterial flora living in the upper portions of the gastro-intestinal tract.

Alessandro Della Cha, CEO of Cosmo, said: 'We are very pleased to expand our agreement with Dr. Falk with whom we have a long relationship. We look forward broadening the indications for this very important product'.

About Cosmo Pharmaceuticals

Cosmo is a specialty pharmaceutical company focused on developing and commercialising products to treat selected gastrointestinal disorders and improve endoscopy quality measures through aiding the detection of colonic lesions. Cosmo has also developed medical devices for endoscopy and has recently entered into a partnership with Medtronic for the global distribution of GI Genius its artificial intelligence device for use in coloscopies and GI procedures. Cosmo has licensed Aemcolo to Red Hill Biopharma Ltd. for the US and has licensed Relafalk to Dr. Falk Gmbh for the EU and other countries.

Contact:

Niall Donnelly

Tel: +353 1 817 03 70

Email: ndonnelly@cosmopharma.com

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