Amongst its highlights, the company plans to initiate a phase 3 study of 4-Factor Prothrombin Complex Concentrate to improve survival in traumatic injury and acute major bleeding, a leading cause of death. In the company's VANGUARD Phase 3 clinical trial for Garadacimab, a monoclonal antibody treatment for hereditary angioedema (HAE), the last patient was enrolled two months ahead of schedule. CSL also progressed recruitment for the AEGIS-II Phase 3 study of CSL112 (ApoA-1) for treatment of acute coronary syndrome despite COVID-19 impact on clinical trial sites and patients. To date, more than 14,000 people have been enrolled in this study.
'We continue to evolve as a leading plasma-based biotechnology company with purposeful diversity in therapeutic areas, scientific platforms and strategic alliances,' said Dr.
The company's Seqirus business, a global leader in influenza prevention, highlighted its R&D investments in its first-of-its-kind adjuvanted, cell-based seasonal influenza vaccine (aQIVc) and next-generation self-amplifying mRNA for seasonal and pandemic influenza (sa-mRNA). Earlier this month, the
Other Seqirus highlights for aQIVc - which combines two leading-edge technologies - the company's proprietary MF59 adjuvant and cell-based vaccine manufacturing - included:
Phase 2 study is ongoing with plans to initiate the Phase 3 clinical trial of this promising vaccine candidate in the second half of 2022.
Both adjuvanted and cell-based influenza vaccines have potential benefits in seasonal influenza vaccine programs compared with more traditional manufacturing methods. Combining the technologies may elicit a greater immune response and potentially result in increased vaccine efficacy, particularly in the older adult population.
Other highlights for the development of Seqirus' next-generation sa-mRNA vaccine technology for seasonal and pandemic influenza included:
Progressing sa-mRNA-based influenza vaccine candidates, with pre-clinical results demonstrating potential.
Targeting the commencement of clinical trials for both seasonal and pandemic influenza vaccine candidates in the second half of 2022.
'We are deeply invested in evolving the vaccine landscape to create new, more effective ways of protecting our communities against both seasonal and pandemic influenza,' said Dr.
Overall, CSL invested more than
New research-industry partnership with the
CSL also announced it is collaborating with WEHI, one of the most prominent medical research and medicine development organizations in
The new Centre combines WEHI's expertise in immunology, cancer, inflammatory disorders, and infectious diseases with CSL's world-class human antibody library and experience in biologic medicine discovery and development.
The Centre will provide access to expert biologic discovery and optimization capabilities accelerating medicine development into the clinic, ultimately addressing a current gap in Australian medical research.
Biologics are made in living systems and encompass a wide range of therapies including monoclonal antibodies, vaccines, growth factors and cell therapies.
Based at WEHI, the Centre aims to generate high-quality and clinic-ready therapeutic antibodies against novel targets in human disease.
The partners will contribute equally to the funding of the Centre with a combined investment of approximately
'CSL's antibody library will be the engine room of biologics discovery at the Centre and, importantly, the knowledge transfer between the two organizations and the utilization of shared assets, resources, and facilities will be of great value,' said Senior Vice President, Head of Research and Chief Scientific Officer Dr.
For more information on this collaboration visit, https://www.wehi.edu.au/news/research-industry-partnership-advance-biologic-therapies.
For more on CSL's R&D Investor Briefing, please visit www.csl.com.
About CSL
CSL (ASX:CSL) is a leading global biotechnology company with a dynamic portfolio of life-saving medicines, including those that treat hemophilia and immune deficiencies, as well as vaccines to prevent influenza. Since our start in 1916, we have been driven by our promise to save lives using the latest technologies. Today, CSL - including our two businesses,
For more information visit www.csl.com.
Contact:
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Email: Jimmy.Baker@csl.com.au
T: +61 450 909 211
E: Joanne.Cleary@seqirus.com
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E: Kim.ODonohue@csl.com.au
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