Item 5.02. Departure of Directors or Certain Officers; Election of Directors;


           Appointment of Certain Officers; Compensatory Arrangements of Certain
           Officers

On and effective August 18, 2021, Kevin B. Churchwell, M.D., resigned from the board of directors of Cyclerion Therapeutics, Inc. (the "Company"). Dr. Churchwell did not advise the Company of any disagreement with the Company on any matter relating to its operations, policies or practices.

Marsha Fanucci, the Chair of the Company's Board of Directors, noted: "I would like to sincerely thank Kevin for his years of service on the Board. We have accepted Kevin's resignation, made in light of his expanded responsibilities and new position as President and Chief Executive Officer of Boston Children's Hospital."


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