Cyclerion Therapeutics, Inc. announced that patient dosing has begun in its Phase 2a study in Alzheimer's Disease with Vascular Pathology (ADv). The Phase 2a ADv study (NCT04798989) is a randomized, placebo-controlled study of oral once-daily CY6463 in approximately 30 participants over a twelve-week dosing period. Study participants must have confirmed Alzheimer's disease pathology as assessed by PET or CSF biomarkers, cardiovascular risk factors, as well as mild-to-moderate subcortical small-vessel disease as assessed by MRI.

The study will evaluate safety, tolerability, and pharmacokinetics as well as explore the impact on various disease-relevant pharmacodynamic biomarkers (e.g., EEG, MRI, neuroinflammatory biomarkers) and cognitive performance.