Item 5.02 Departure of Directors or Certain Officers; Election of Directors;

Appointment of Certain Officers; Compensatory Arrangements of Certain

Officers.

On March 11, 2022 the Board of Directors of CymaBay Therapeutics, Inc. (the "Board") appointed Éric Lefebvre to the Board, effective as of March 21, 2022.

As a non-employee director, Dr. Lefebvre will receive compensation in accordance with CymaBay's non-employee director compensation program. Pursuant to this program, on March 21, 2022 (the effective date of his appointment), Dr. Lefebvre will receive a stock option award to acquire 115,000 shares of CymaBay common stock (with an approximate grant date fair value of $300,000), which will vest in 36 equal monthly installments from March 21, 2022, subject to continued service to CymaBay through such dates. He will also be eligible for an annual cash retainer in the amount of $40,000 for his service as a member of the Board. Dr. Lefebvre will also enter into an indemnification agreement with CymaBay consistent with the form agreement executed with each of CymaBay's current executive officers and directors. As of the date hereof the Board has not yet determined upon which Board committees Dr. Lefebvre will serve.

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