- Research collaboration leverages Oncorus’ proprietary ionizable amines, PEG lipids, LNP formulations, process development and manufacturing together with Daewoong’s mRNA expertise
- Opportunity for future license, manufacturing and supply agreement for formulated drug candidates
Under the terms of the collaboration,
“This collaboration is important validation for our proprietary LNP platform, which is comprised of both novel ionizable amines and cleavable PEG lipids for both intravenous and intramuscular administration, and we are excited to develop novel LNP formulations for Daewoong’s RNA-based programs,” said
“mRNA is now known to be a powerful tool in our ability to fight many diseases,” said
Oncorus’ LNP platform leverages proprietary ionizable and polyethylene glycol (PEG) lipids for multiple nucleic acid cargos and possesses other desirable physiochemical properties. In multiple preclinical models involving repeat intravenous (IV) dosing, Oncorus’ formulations have demonstrated improved tolerability, an enhanced therapeutic window and consistent pharmacokinetics compared to approved formulations. Similar studies incorporating Oncorus’ LNP formulations have demonstrated low immunogenicity along with other desirable attributes, including tunable pharmacokinetics with different compositions and stable pharmacokinetics following repeat dosing. The platform is designed to efficiently deliver nucleic acids, including large cargos up to 14 kilobases. This delivery strategy is intended to address many of the complications associated with anti-PEG antibodies interfering with the effective IV delivery of RNA and other nucleic acid-based medicines and can also be leveraged for vaccine applications.
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Cautionary Note Regarding Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, implied and express statements regarding Oncorus’ plans to develop formulated drug in accordance with the research collaboration with Daewoong; the parties plans to commence negotiation of a subsequent license and manufacturing and supply arrangement for the formulated drug; the promise of LNP-based delivery mechanisms; and the opportunity for future partnerships relative to Oncorus’ LNP platform. The words “may,” “might,” “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “expect,” “estimate,” “seek,” “predict,” “future,” “project,” “potential,” “continue,” “target” and similar words or expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on management’s current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, risks associated with: Oncorus’ ability to successfully demonstrate the safety, tolerability and efficacy of its product candidates and obtain regulatory approval thereof; the adequacy of Oncorus’ existing capital resources and availability of financing on commercially reasonable terms; Oncorus’ ability to obtain the requisite components for its product candidates manufactured in accordance with regulatory requirements; the expansion of Oncorus’ in-house manufacturing capabilities and its ability to manufacture product at clinical and commercial scales; the impact of COVID-19 on Oncorus’ operations and the timing and anticipated results of its ongoing and planned clinical trials; the accuracy of the Oncorus’ estimates regarding expenses, future revenue, capital requirements and needs for additional financing; and Oncorus’ ability to obtain, maintain and protect its intellectual property. These and other risks and uncertainties are described in greater detail in the section entitled “Risk Factors” in Oncorus’ Annual Report on Form 10-K for the year ended
Oncorus Investor Contact:
Stern Investor Relations
Julie.seidel@sternir.com
Daewoong Pharmaceutical Investor Contact:
thierryur@daewoong.co.kr
Source:
2023 GlobeNewswire, Inc., source