| | Change | 5d. change | 1st Jan change | 1-year change | 3-years change | Capi. (M$) |
 | DECIPHERA PHARMACEUTICALS, INC. | -0.18% | -5.92% | 3.78% | 101.78% | -72.84% | 1 285 |
| | | | | | | |
| VERTEX PHARMACEUTICALS | 0.98% | 3.75% | 11.88% | 32.94% | 42.30% | 82 136 |
| REGENERON PHARMACEUTICALS, INC. | 2.99% | 2.89% | 5.13% | 24.63% | 124.44% | 78 655 |
 | WUXI APPTEC CO., LTD. | -3.21% | -1.56% | 15.12% | -11.02% | 63.55% | 41 845 |
| BIONTECH SE | 2.08% | 0.61% | -4.53% | -16.66% | 390.96% | 34 142 |
| BEIGENE, LTD. | -0.06% | -4.78% | 16.40% | 5.53% | 68.02% | 26 628 |
 | GENMAB A/S | 0.38% | -2.17% | -9.15% | 24.57% | 71.23% | 25 417 |
 | ARGENX SE | 0.12% | -4.52% | -0.37% | 53.00% | 164.68% | 20 887 |
| SAREPTA THERAPEUTICS, INC. | 3.40% | -5.82% | -3.56% | 74.61% | 7.77% | 10 609 |
| NEUROCRINE BIOSCIENCES, INC. | 2.44% | -0.42% | -7.12% | 40.38% | 10.84% | 10 410 |
| LEGEND BIOTECH CORPORATION | 0.74% | -7.13% | 1.16% | 18.43% | --.--% | 8 392 |
| HALOZYME THERAPEUTICS, INC. | 1.27% | -0.58% | -9.02% | 49.58% | 172.76% | 6 912 |
| ASCENDIS PHARMA A/S | 2.72% | -2.42% | 1.60% | 2.01% | -8.16% | 6 764 |
| KARUNA THERAPEUTICS, INC. | 2.25% | -0.76% | 1.47% | 79.53% | 110.08% | 6 701 |
 | REMEGEN CO., LTD. | -2.40% | -2.27% | 8.81% | 30.98% | --.--% | 5 929 |
| EXELIXIS, INC. | 1.32% | 2.17% | 9.85% | -2.65% | 2.44% | 5 609 |
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