Item 1.01. Entry into a Material Definitive Agreement.

As previously disclosed, on July 1, 2021, DermTech, Inc., or the Company, entered into an Office Lease, or the Original Lease Agreement, dated July 1, 2021, with Kilroy Realty, L.P., or the Landlord, with respect to an aggregate of 95,997 rentable square feet, consisting of the entire building located at 12340 El Camino Real, San Diego, California 92130, or the Building. The Original Lease Agreement was subsequently amended by the First Amendment to Office Lease and the Second Amendment to Office Lease, each dated April 22, 2022.

Pursuant to the Original Lease Agreement, tenants of the "Del Mar Corporate Centre II" office project, or the Project, which consists of the Building and the adjacent office building located at 12390 El Camino Real, San Diego, California 92130, or the Adjacent Building, have access to a fitness center, or the Fitness Center, located at the Adjacent Building.

On November 11, 2022, the Company entered into a Third Amendment to Office Lease, or the Third Amendment, dated effective as of October 7, 2022, with the Landlord. Pursuant to the Third Amendment, the Company and the Landlord agreed that beginning January 1, 2023, the Fitness Center shall be used exclusively by another tenant of the Project. As a result, the measurement of the Expansion Premises (as defined in the Second Amendment) will be reduced from 14,085 rentable square feet of space to 13,310 rentable square feet of space, and the Company's monthly installment of base rent for the Expansion Premises will be reduced as set forth in Schedule 1 of the Third Amendment.

The foregoing summary is qualified in its entirety by reference to the full text of the Third Amendment, a copy of which is filed as Exhibit 10.1 hereto and is incorporated by reference herein.

Item 9.01. Financial Statements and Exhibits.



(d)Exhibits.

    Exhibit
      No.                                              Description

                        Third Amendment to Office Lease, dated effective October 7, 2022, by and
     10.1             between the Company and Kilroy Realty, L.P.
      104             Cover Page Interactive Data File (embedded within the Inline XBRL document).


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